Title:
Regulator of TGR5 Signaling as Immunomodulatory Agent
Document Type and Number:
WIPO Patent Application WO/2020/063632
Kind Code:
A1
Abstract:
The present disclosure provides methods of enhancing immunity, comprising administering TGR5 agonist such as a bile acid (BA) to a subject in need thereof. Provided also herein are methods of inhibiting immunity, comprising administering TGR5 antagonist to a subject in need thereof. The present disclosure further provides methods of identifying immunomodulatory agent, comprising contacting TGR5 with a candidate agent.
Inventors:
SHU HONGBING (CN)
HU MINGMING (CN)
HU MINGMING (CN)
Application Number:
PCT/CN2019/107719
Publication Date:
April 02, 2020
Filing Date:
September 25, 2019
Export Citation:
Assignee:
YICHANG HUMANWELL PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/575; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P35/02
Domestic Patent References:
| WO1994000126A1 | 1994-01-06 | |||
| WO2014200349A1 | 2014-12-18 |
Foreign References:
| US4681876A | 1987-07-21 | |||
| CN103919787A | 2014-07-16 | |||
| US20150313991A1 | 2015-11-05 |
Other References:
See also references of EP 3856197A4
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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