REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO

Title:

REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO

Document Type and Number:

WIPO Patent Application WO2001027135

Kind Code:

A9

Abstract:

The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.

Inventors:

BEACHY PHILIP A

Application Number:

PCT/US2000/028479

Publication Date:

August 15, 2002

Filing Date:

October 13, 2000

Export Citation:

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Assignee:

UNIV JOHNS HOPKINS MED (US)

International Classes:

A61P1/02; A61P1/16; A61K31/58; A61P1/18; A61P11/00; A61P15/16; A61P15/18; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/08; A61P17/12; A61P17/14; A61P17/16; A61P19/02; A61P19/04; A61P19/08; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; A61P27/00; A61P27/12; A61P35/00; A61P43/00; C07J69/00; (IPC1-7): C07J69/00; A61K31/58

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