Title:
RELATION OF APOLIPOPROTEIN E GENOTYPE AND ESTROGEN DEPRIVATION IN ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO2001031064
Kind Code:
A3
Abstract:
A method of screening a subject for risk of developing Alzheimer's disease comprises determining the presence of at least one ApoE4 allele in a subject, and determining the presence or absence of decreased estrogen levels in said subject (e.g., due to previous or impending menopause or hysterectomy). The presence of at least one ApoE4 allele (and particularly two ApoE4 alleles) in combination with decreased estrogen levels in said subject indicating said subject is at greater risk of developing Alzheimer's disease (e.g., as compared to subjects with at corresponding number of ApoE4 alleles, but who do not have decreased estrogen levels), and that the subject will receive greater benefit from estrogen replacement therapy in treating Alzheimer's disease than a subject who does not carry one or two ApoE4 alleles.
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Inventors:
EINSTEIN GILLIAN (US)
SHAUGHNESSY LAURA W (US)
SCHMECHEL DONALD E (US)
SHAUGHNESSY LAURA W (US)
SCHMECHEL DONALD E (US)
Application Number:
PCT/US2000/041177
Publication Date:
May 30, 2002
Filing Date:
October 16, 2000
Export Citation:
Assignee:
UNIV DUKE (US)
EINSTEIN GILLIAN (US)
SHAUGHNESSY LAURA W (US)
SCHMECHEL DONALD E (US)
EINSTEIN GILLIAN (US)
SHAUGHNESSY LAURA W (US)
SCHMECHEL DONALD E (US)
International Classes:
C12Q1/68; (IPC1-7): C12Q1/68
Domestic Patent References:
| WO1999020646A1 | 1999-04-29 | |||
| WO1998043647A1 | 1998-10-08 | |||
| WO1995029257A2 | 1995-11-02 |
Foreign References:
| US5773220A | 1998-06-30 | |||
| US5508167A | 1996-04-16 | |||
| US5422119A | 1995-06-06 |
Other References:
J W SIMPKINS: "The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease", NEUROBIOLOGY OF AGING,US,TARRYTOWN, NY, vol. 15, no. SUPPL. 02, 1994, pages S195 - S197-S1,97, XP002104181, ISSN: 0197-4580
STONE DAVID J ET AL: "Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: Implications for Alzheimer's disease.", JOURNAL OF NEUROSCIENCE, vol. 18, no. 9, 1 May 1998 (1998-05-01), pages 3180 - 3185, XP002172907, ISSN: 0270-6474
INESTROSA NIBALDO C ET AL: "Cellular and molecular basis of estrogen's neuroprotection: Potential relevance for Alzheimer's disease.", MOLECULAR NEUROBIOLOGY, vol. 17, no. 1-3, 1 January 1998 (1998-01-01), pages 73 - 86, XP001010530, ISSN: 0893-7648
CRAWFORD J G: "Alzheimer's disease risk factors as related to cerebral blood flow: Additional evidence.", MEDICAL HYPOTHESES, vol. 50, no. 1, January 1998 (1998-01-01), pages 25 - 36, XP001010506, ISSN: 0306-9877
SHAUGHNESSY L W ET AL: "The effects of APOE allelic variation and estrogen deprivation on synapto-dendritic relationships in the hippocampus of aging female transgenic mice.", SOCIETY FOR NEUROSCIENCE ABSTRACTS., vol. 25, no. 1-2, 22 October 1999 (1999-10-22), 29th Annual Meeting of the Society for Neuroscience.;Miami Beach, Florida, USA; October 23-28, 1999, pages 1345, XP001010526, ISSN: 0190-5295
STONE DAVID J ET AL: "Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: Implications for Alzheimer's disease.", JOURNAL OF NEUROSCIENCE, vol. 18, no. 9, 1 May 1998 (1998-05-01), pages 3180 - 3185, XP002172907, ISSN: 0270-6474
INESTROSA NIBALDO C ET AL: "Cellular and molecular basis of estrogen's neuroprotection: Potential relevance for Alzheimer's disease.", MOLECULAR NEUROBIOLOGY, vol. 17, no. 1-3, 1 January 1998 (1998-01-01), pages 73 - 86, XP001010530, ISSN: 0893-7648
CRAWFORD J G: "Alzheimer's disease risk factors as related to cerebral blood flow: Additional evidence.", MEDICAL HYPOTHESES, vol. 50, no. 1, January 1998 (1998-01-01), pages 25 - 36, XP001010506, ISSN: 0306-9877
SHAUGHNESSY L W ET AL: "The effects of APOE allelic variation and estrogen deprivation on synapto-dendritic relationships in the hippocampus of aging female transgenic mice.", SOCIETY FOR NEUROSCIENCE ABSTRACTS., vol. 25, no. 1-2, 22 October 1999 (1999-10-22), 29th Annual Meeting of the Society for Neuroscience.;Miami Beach, Florida, USA; October 23-28, 1999, pages 1345, XP001010526, ISSN: 0190-5295
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