Title:
REMEDIES FOR DISEASES CAUSED BY VASCULAR CONTRACTION OR DILATION
Document Type and Number:
WIPO Patent Application WO/2004/002531
Kind Code:
A1
Abstract:
Remedies and/or preventives for diseases caused by vascular contraction or dilation which comprise EDG-5 regulators. EDG-5 regulators specifically bind to EDG-5 and show antagonism or agonism. Thus, an EDG-5 antagonist is useful in treating and/or preventing diseases caused by vascular contraction such as cerebrovascular spasmodic disease following subarachnoid hemorrhage or cerebral infarction, cardiovascular spasmodic disease, hypertension, kidney diseases, cardiac infarction, angina, arrhythmia, portal hypertension in association with cirrhosis and varicosity in association with cirrhosis. On the other hand, an EDG-5 agonist is useful in treating and/or preventing diseases caused by vascular dilation such as chronic headache (for example, hemicrania, tension headache, headache of the mixed type, cluster headache), hemorrhoid and cardiac diseases.
Inventors:
NAKADE SHINJI (JP)
SUZUKI HIDEHIRO (JP)
HABASHITA HIROMU (JP)
SUZUKI HIDEHIRO (JP)
HABASHITA HIROMU (JP)
Application Number:
PCT/JP2003/008039
Publication Date:
January 08, 2004
Filing Date:
June 25, 2003
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
NAKADE SHINJI (JP)
SUZUKI HIDEHIRO (JP)
HABASHITA HIROMU (JP)
NAKADE SHINJI (JP)
SUZUKI HIDEHIRO (JP)
HABASHITA HIROMU (JP)
International Classes:
A61K31/437; A61K31/445; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P9/14; A61P13/12; A61P25/06; A61P43/00; C07D211/48; C07D471/04; C07D519/00; (IPC1-7): A61K45/00; A61K31/437; A61K31/445; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P9/14; A61P13/12; A61P25/06; A61P43/00; C07D471/04
Domestic Patent References:
| WO2001069252A1 | 2001-09-20 | |||
| WO2001098301A1 | 2001-12-27 | |||
| WO2003051876A1 | 2003-06-26 | |||
| WO2001003739A1 | 2001-01-18 | |||
| WO2001003739A1 | 2001-01-18 | |||
| WO2001098301A1 | 2001-12-27 | |||
| WO1999007672A1 | 1999-02-18 |
Foreign References:
| US3542793A | 1970-11-24 | |||
| US4612318A | 1986-09-16 | |||
| JP2001261575A | 2001-09-26 |
Other References:
OKAZAKI H.: "Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 190, no. 3, 15 February 1993 (1993-02-15), pages 1104 - 1109, XP002929595
OHMORI T.: "Sphingosine 1-phophate induces contraction of coronary artery smooth muscle cells via S1P2", CARDIOVASC. RES., vol. 58, no. 1, 1 April 2003 (2003-04-01), pages 170 - 177, XP002964741
EUR. J. NEUROSCI., vol. 14, 2001, pages 203
J. BIOL. CHEM., 2002
See also references of EP 1522314A4
OHMORI T.: "Sphingosine 1-phophate induces contraction of coronary artery smooth muscle cells via S1P2", CARDIOVASC. RES., vol. 58, no. 1, 1 April 2003 (2003-04-01), pages 170 - 177, XP002964741
EUR. J. NEUROSCI., vol. 14, 2001, pages 203
J. BIOL. CHEM., 2002
See also references of EP 1522314A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Horiguchi No.2 Bldg. 7F 2-6,
Nihonbashi-Ningyocho, 2-chom, Chuo-ku Tokyo, JP)
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