Title:
REMEDIES FOR NEUROPATHIC PAIN
Document Type and Number:
WIPO Patent Application WO/2000/061558
Kind Code:
A1
Abstract:
Compounds represented by general formula (I) or salts thereof and medicinal compositions containing the same as the active ingredient: wherein A represents, for example, phenyl substituted by R?1¿ and R?2¿, unsubstituted furyl or unsubstituted thienyl (wherein R?1¿ represents, for example, hydrogen, fluoro, chloro, trifuloromethyl, nitro, cyano or methyl; and R?2¿ represents, for example, hydrogen); R?3¿ represents, for example, hydrogen or methyl; R?4¿ represents, for example, hydrogen or methyl; R?5¿ represents ethoxy or iso-propoxy; X represents -CH(OH)- or methylene; and Z represents, for example, a single bond or optionally hydroxylated methylene. These compounds can be orally administered as remedies for neuropathic pain and exhibit excellent effect while showing littLe side effects.
Inventors:
Yamamoto, Ichiro (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-k, Tokyo, 160-8515, JP)
Itoh, Manabu (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Yamasaki, Fumiaki (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Akada, Yasushige (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Miyazaki, Yutaka (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Ogawa, Shinichi (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Itoh, Manabu (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Yamasaki, Fumiaki (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Akada, Yasushige (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Miyazaki, Yutaka (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Ogawa, Shinichi (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Application Number:
PCT/JP2000/002332
Publication Date:
October 19, 2000
Filing Date:
April 10, 2000
Export Citation:
Assignee:
MOCHIDA PHARMACEUTICAL CO., LTD. (7 Yotsuya 1-chome Shinjuku-ku, Tokyo, Tokyo, 160-8515, JP)
Yamamoto, Ichiro (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-k, Tokyo, 160-8515, JP)
Itoh, Manabu (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Yamasaki, Fumiaki (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Akada, Yasushige (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Miyazaki, Yutaka (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Ogawa, Shinichi (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Yamamoto, Ichiro (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-k, Tokyo, 160-8515, JP)
Itoh, Manabu (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Yamasaki, Fumiaki (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Akada, Yasushige (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Miyazaki, Yutaka (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
Ogawa, Shinichi (Mochida Pharmaceutical Co, Ltd. 7 Yotsuya 1-chome Shinjuku-ku, Tokyo, 160-8515, JP)
International Classes:
A61P25/04; A61P29/02; C07D211/48; C07D405/06; C07D407/06; C07D409/06; (IPC1-7): C07D211/48; C07D405/06; C07D409/06; G01N33/483; A61K31/445; A61K31/4525; A61K31/4535; A61P25/04; A61P29/02
Attorney, Agent or Firm:
Hanabusa, Tsuneo (Hanabusa Patent Office, Ochanomizu Square B 6 Kandasurugadai 1-chome Chiyoda-ku, Tokyo, 101-0062, JP)
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