REMEDIES OR PREVENTIVES FOR URINARY FREQUENCY OR URINARY INCONTINENCE AND MORPHINAN DERIVATIVES HAVING NITROGEN-CONTAINING HETEROCYCLIC GROUP

Title:

REMEDIES OR PREVENTIVES FOR URINARY FREQUENCY OR URINARY INCONTINENCE AND MORPHINAN DERIVATIVES HAVING NITROGEN-CONTAINING HETEROCYCLIC GROUP

Document Type and Number:

WIPO Patent Application WO/2004/033457

Kind Code:

A1

Abstract:

It is intended to provide a morphinan derivative represented by the following general formula (I): (I) wherein R¹ represents methyl, cyclopropylmethyl, etc.; R² and R³ represent each hydroxy, methoxy, acetoxy, etc.; Y and Z represent each a valence bond, -(C=O)-, etc.; X represents a C_2-5 carbon chain constituting a part of the cyclic structure (wherein one of the carbon atoms may be substituted by oxygen, sulfur or nitrogen); (R⁴)_k represents an optionally substituted fused benzene ring, carbonyl, etc.; R⁹ represents hydrogen, etc.; R¹⁰ and R¹¹ may be bonded together to form -O-; and R⁶ represents hydrogen, etc.; a pharmacologically acceptable acid addition salt thereof, a remedy or a preventive for urinary frequency or urinary incontinence containing the above derivative or its pharmacologically acceptable acid addition salt as the active ingredient; a method for treating or preventing the above diseases; and utilization for these diseases. The above-described compound is useful as a novel remedy or preventive for urinary frequency or urinary incontinence showing an isolated side effect. Moreover, it is useful in a method for treating or preventing the above diseases and utilization for these diseases.

Inventors:

IZUMIMOTO NAOKI (JP)
KAWAI KOJI (JP)
KAWAMURA KUNIAKI (JP)
FUJIMURA MORIHIRO (JP)
KOMAGATA TOSHIKAZU (JP)

Application Number:

PCT/JP2003/012890

Publication Date:

April 22, 2004

Filing Date:

October 08, 2003

Export Citation:

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Assignee:

TORAY INDUSTRIES (JP)
IZUMIMOTO NAOKI (JP)
KAWAI KOJI (JP)
KAWAMURA KUNIAKI (JP)
FUJIMURA MORIHIRO (JP)
KOMAGATA TOSHIKAZU (JP)

International Classes:

A61P13/00; A61P13/02; C07D489/08; (IPC1-7): C07D489/00; A61K31/485; A61P13/00; A61P13/02

Domestic Patent References:

WO2001005795A1	2001-01-25
WO2002080918A1	2002-10-17

Foreign References:

JPH11501627A

1999-02-09

Other References:

See also references of EP 1555266A4
None

Attorney, Agent or Firm:

Tanigawa, Hidejiro c/o Tanigawa and Associates (Patent Firm 6F, Iwata Bldg., 5-12, Iidabashi 4-chom, Chiyoda-ku Tokyo, JP)

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