Title:
REMEDIES FOR TUMOR IN HEMATOPOIETIC ORGANS
Document Type and Number:
WIPO Patent Application WO/2002/064159
Kind Code:
A1
Abstract:
HM1.24 antigen expression inducers or potentiators in tumor cells in hematopoietic organs which contain as the active ingredient interferon $g(a), interferon $g(b) or IRF-2 protein; and antitumor agents for tumor in hematopoietic organs comprising these inducing agents or potentiators combined with an antibody against HM1.24.
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Inventors:
KOSAKA MASAAKI (JP)
OZAKI SHUJI (JP)
WAKAHARA YUJI (JP)
OZAKI SHUJI (JP)
WAKAHARA YUJI (JP)
Application Number:
PCT/JP2002/000989
Publication Date:
August 22, 2002
Filing Date:
February 06, 2002
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
KOSAKA MASAAKI (JP)
OZAKI SHUJI (JP)
WAKAHARA YUJI (JP)
KOSAKA MASAAKI (JP)
OZAKI SHUJI (JP)
WAKAHARA YUJI (JP)
International Classes:
A61K38/17; A61K38/21; A61K39/395; A61P19/00; A61P35/00; A61P35/02; C07K14/555; C07K16/30; C12N5/07; C12N5/077; C12N5/0781; C12N5/0783; C12N5/0784; C12N5/09; C12N15/12; G01N33/574; (IPC1-7): A61K38/21; A61K38/17; A61K39/395; A61K45/00; A61P35/00; A61P35/02; A61P19/00; C12Q1/02; C12Q1/66; C12Q1/68; C12N15/12; C07K14/705; C07K16/28
Domestic Patent References:
| WO1994006818A1 | 1994-03-31 | |||
| WO1999018997A1 | 1999-04-22 | |||
| WO2001013940A1 | 2001-03-01 | |||
| WO2001097844A1 | 2001-12-27 |
Foreign References:
| EP0997152A1 | 2000-05-03 |
Other References:
DATABASE BIOSIS [online] OZAKI S. ET AL.: "Interferon-alpha and -gamma enhance the HM1. 24 expression of myeloma cells through the STAT-signaling pathway", XP002934316, Database accession no. 2000:47072
KOENING MEREDIZ S.A. ET AL.: "Cloning of an interferon regulatory factor 2 isoform with different regulatory ability", NUCLEIC ACIDS RES., vol. 28, no. 21, 1 November 2000 (2000-11-01), pages 4219 - 4224, XP002956372
OZAKI S. ET AL.: "Humanized anti-HM1.24 antibody mediates myeloma cell cytotoxicity that is enhanced by cytokine stimulation of effector cells", BLOOD, vol. 93, no. 11, 1999, pages 3922 - 3930, XP002214462
See also references of EP 1364657A4
KOENING MEREDIZ S.A. ET AL.: "Cloning of an interferon regulatory factor 2 isoform with different regulatory ability", NUCLEIC ACIDS RES., vol. 28, no. 21, 1 November 2000 (2000-11-01), pages 4219 - 4224, XP002956372
OZAKI S. ET AL.: "Humanized anti-HM1.24 antibody mediates myeloma cell cytotoxicity that is enhanced by cytokine stimulation of effector cells", BLOOD, vol. 93, no. 11, 1999, pages 3922 - 3930, XP002214462
See also references of EP 1364657A4
Attorney, Agent or Firm:
Ishida, Takashi (ISHIDA & ASSOCIATES Toranomon 37 Mori
Bldg., 5-1, Toranomon 3-chom, Minato-ku Tokyo, JP)
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