REMEDY FOR INFLAMMATORY BOWEL DISEASE - STELIC INSTITUTE REGENERATIVE MEDICINE

Title:

REMEDY FOR INFLAMMATORY BOWEL DISEASE

Document Type and Number:

WIPO Patent Application WO/2008/020489

Kind Code:

A1

Abstract:

The inventor found for the first time that bowel inflammation can be efficiently inhibited by inhibiting the formation or accumulation of chondroitin sulfate proteoglycan. That is, by inhibiting the expression of versican which is one of the chondroitin sulfate proteoglycans using siRNA, inflammation in the large bowel could be inhibited. A compound such as a nucleic acid to be used for such an siRNA can be used as an agent effective in the inhibition of bowel inflammation. Further, this also indicates that the agent for inhibiting bowel inflammation can be found by screening a compound inhibiting the formation or accumulation of chondroitin sulfate proteoglycan.

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Inventors:

YONEYAMA HIROYUKI (JP)
WAKAMATSU KYOKO (JP)

Application Number:

PCT/JP2006/323673

Publication Date:

February 21, 2008

Filing Date:

November 28, 2006

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Assignee:

STELIC INSTITUTE REGENERATIVE MEDICINE (JP)
YONEYAMA HIROYUKI (JP)
WAKAMATSU KYOKO (JP)

International Classes:

A61K31/7088; A61K45/00; A61K38/00; A61P1/00; A61P29/00; C12Q1/00; G01N33/15; G01N33/50

Domestic Patent References:

WO2001035977A2

2001-05-25

Foreign References:

JP2001327297A	2001-11-27
JP2001309794A	2001-11-06
JP2002330761A	2002-11-19
JP2002330762A	2002-11-19
US6689748B1	2004-02-10

Attorney, Agent or Firm:

SHIMIZU, Hatsushi et al. (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki 47, JP)

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