REMOVAL OF ALDEHYDE IMPURITY BY REACTIVE POLYSTYRENE RESIN

Title:

REMOVAL OF ALDEHYDE IMPURITY BY REACTIVE POLYSTYRENE RESIN

Document Type and Number:

WIPO Patent Application WO2004026794

Kind Code:

A3

Abstract:

A purification method in the preparation of a substituted 8-arylquinoline, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, utilizes a polystyrene-based sulfonylhydrazine reactive resin to remove an aldehyde impurity.

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Inventors:

BIBA MIRLINDA (US)
COLLINS PAUL COMPTON (US)
WELCH CHRISTOPHER JOSEPH (US)
CONLON DAVID A (US)
DRAHUS ANTOINETTE (US)

Application Number:

PCT/US2003/028716

Publication Date:

June 17, 2004

Filing Date:

September 12, 2003

Export Citation:

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Assignee:

MERCK & CO INC (US)
BIBA MIRLINDA (US)
COLLINS PAUL COMPTON (US)
WELCH CHRISTOPHER JOSEPH (US)
CONLON DAVID A (US)
DRAHUS ANTOINETTE (US)

International Classes:

C07D413/10; (IPC1-7): A61K31/4709; A61K31/47; C07D215/14; C07D401/10; C07D413/10

Foreign References:

US6410563B1

2002-06-25

Other References: