Title:
RENAL TARGETING-TYPE DRUG DELIVERY CARRIER HAVING EXCELLENT BIODEGRABILITY
Document Type and Number:
WIPO Patent Application WO/2021/002481
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a drug delivery carrier which can be accumulated selectively in the kidney in vivo and which can show high biodegrability and drug-release capability in the kidney. The present invention relates to: a compound having such a structure that a carbonyl group in a serine residue is linked to a terminal amino group in a linear polylysine molecule directly or through a linker; a drug delivery carrier comprising the compound; and a medicine for diagnosing, preventing or treating a renal disease, which comprises the drug delivery carrier and a drug that is bonded to the drug delivery carrier directly or through a linker or is encapsulated in the drug delivery carrier.
Inventors:
KATSUMI HIDEMASA (JP)
YAMAMOTO AKIRA (JP)
YAMAMOTO AKIRA (JP)
Application Number:
PCT/JP2020/026618
Publication Date:
January 07, 2021
Filing Date:
July 01, 2020
Export Citation:
Assignee:
KYOTO PHARMACEUTICAL UNIV (JP)
International Classes:
A61K45/00; A61K31/7088; A61K31/7105; A61K31/711; A61K31/713; A61K47/42; A61K47/62; A61K47/64; A61K48/00; A61K49/00; A61K51/00; A61K51/08; A61P7/02; A61P13/12; A61P35/00; C07K14/00
Domestic Patent References:
| WO2019009436A1 | 2019-01-10 | |||
| WO2019009436A1 | 2019-01-10 |
Foreign References:
| JP2004340722A | 2004-12-02 | |||
| JP2019123540A | 2019-07-25 |
Other References:
HUDECZ, F. ET AL.: "Carrier design: New generation of polycationic branched polypeptides containing OH groups with prolonged blood survival and diminished in vitro cytotoxicity", BIOCONJUGATE CHEMISTRY, vol. 10, 1999, pages 781 - 790, XP000854009, DOI: 10.1021/bc990015q
YAMASAKI, Y. ET AL., J. PHARMACOL. EXP., vol. 301, no. 2, May 2002 (2002-05-01), pages 467 - 477
KAMADA, H. ET AL., NAT BIOTECHNOL., vol. 21, no. 4, 2003, pages 399 - 404
MATSUURA, S. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 115, no. 41, 2018, pages 10511 - 10516
MATSUURA, S. ET AL., PHARMACEUTICS, vol. 10, no. 4, 2018, pages E251
CHENG, Y. ET AL., CHEM. SOC. REV., vol. 40, 2011, pages 2673 - 2703
HABEEB AF, ANAL. BIOCHEM., vol. 14, 1966, pages 328 - 336
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
NISHIKAWA, M. ET AL., BIOL. PHARM. BULL., vol. 22, no. 2, 1999, pages 214 - 218
HNATOWICH, D. J. ET AL., INT. J. APPL. RADIAT. ISOT., vol. 33, no. 5, 1982, pages 327 - 332
AUNG ET AL., ONCOTARGET, vol. 7, 2016, pages 38835 - 38844
YAMASAKI, Y. ET AL., J. PHARMACOL. EXP., vol. 301, no. 2, May 2002 (2002-05-01), pages 467 - 477
KAMADA, H. ET AL., NAT BIOTECHNOL., vol. 21, no. 4, 2003, pages 399 - 404
MATSUURA, S. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 115, no. 41, 2018, pages 10511 - 10516
MATSUURA, S. ET AL., PHARMACEUTICS, vol. 10, no. 4, 2018, pages E251
CHENG, Y. ET AL., CHEM. SOC. REV., vol. 40, 2011, pages 2673 - 2703
HABEEB AF, ANAL. BIOCHEM., vol. 14, 1966, pages 328 - 336
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
NISHIKAWA, M. ET AL., BIOL. PHARM. BULL., vol. 22, no. 2, 1999, pages 214 - 218
HNATOWICH, D. J. ET AL., INT. J. APPL. RADIAT. ISOT., vol. 33, no. 5, 1982, pages 327 - 332
AUNG ET AL., ONCOTARGET, vol. 7, 2016, pages 38835 - 38844
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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