Title:
REPLACEMENT THERAPY FOR NATRIURETIC PEPTIDE DEFICIENCIES
Document Type and Number:
WIPO Patent Application WO/2015/175502
Kind Code:
A3
Abstract:
Use and methods of use of natriuretic peptide mimetics which bind to and activate natriuretic peptide receptor A in patients with a defect, condition, syndrome, disease or mutation resulting in a functional active ΑΝΡ99-126 deficiency, for treatment or prophylaxis of cardiovascular disease, including but not limited to hypertension, acute coronary syndrome, cardiomyopathy, cardiac remodeling, left-ventricular hypertrophy, congestive heart failure, heart failure, high blood pressure and coronary artery disease, including use of mimetics with a plurality of amino acid residues and at least one amino acid surrogate of formula (I) where R, R', Q, Y, W, Z, J, x and n are as defined in the specification.
Inventors:
SPANA CARL (US)
DODD JOHN H (US)
HALLAM TREVOR (US)
DODD JOHN H (US)
HALLAM TREVOR (US)
Application Number:
PCT/US2015/030324
Publication Date:
December 30, 2015
Filing Date:
May 12, 2015
Export Citation:
Assignee:
PALATIN TECHNOLOGIES INC (US)
International Classes:
C07K14/58; A61K38/22
Domestic Patent References:
| WO2007115182A2 | 2007-10-11 | |||
| WO2013188787A1 | 2013-12-19 | |||
| WO2011133735A2 | 2011-10-27 | |||
| WO2008100800A1 | 2008-08-21 |
Foreign References:
| US20080045444A1 | 2008-02-21 | |||
| US20060019890A1 | 2006-01-26 | |||
| US20040077027A1 | 2004-04-22 |
Other References:
SICA, D, MD ET AL.: "Phase IIa Study Of The NPR-Agonist, PL -3994", IN HEALTHY ADULT VOLUNTEERS WITH CONTROLLED HYPERTENSION, September 2009 (2009-09-01), pages 1, XP055245665, Retrieved from the Internet [retrieved on 20150929]
Attorney, Agent or Firm:
SLUSHER, Stephen, A. (Inc.4B Cedar Brook Driv, Cranbury NJ, US)
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