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Title:
REPLICATION INCOMPETENT HERPES SIMPLEX VIRUS TYPE 1 VIRAL VACCINE
Document Type and Number:
WIPO Patent Application WO/2024/027810
Kind Code:
A1
Abstract:
Disclosed is a replication incompetent HSV-1 viral vaccine comprising a modified genome of HSV-1 and at least one antigen. The modification comprises a deletion of internal repeats, an inactivating mutation in ICP47 and an inactivating mutation in the other copy of ICP4. A first antigen of the at least one antigen is driven by a promoter of an immediate early gene, such as ICP4. In a specific example, the HSV-1 viral vaccine expresses antigens from SARS-Cov, SARS-Cov-2 and variants thereof and is used for inducing immune responses against sarbecoviruses in a subject to which the vaccine is administered.

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Inventors:
LIU YUANYUAN (CN)
LIU YONGHONG (CN)
DENG TIANYI (CN)
ZENG YUYUN (CN)
CHEN XIAOQING (CN)
ZHOU GRACE GUOYING (CN)
Application Number:
PCT/CN2023/111125
Publication Date:
February 08, 2024
Filing Date:
August 04, 2023
Export Citation:
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Assignee:
IMMVIRA BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
A61K39/245; C12N7/00
Foreign References:
US20040022812A12004-02-05
US6248320B12001-06-19
US20170202952A12017-07-20
US20140363469A12014-12-11
US20030215463A12003-11-20
Attorney, Agent or Firm:
WINGUAN PATENT AND TRADEMARK ATTORNEYS (CN)
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