Title:
RESOLUTION OF 4,5-DIMETHOXY-1-(METHYLAMINOMETHYL)-BENZOCYCLOBUTANE
Document Type and Number:
WIPO Patent Application WO/2009/062377
Kind Code:
A1
Abstract:
A method of resolution of an important chemical intermediate, 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane,
comprises the following steps: reacted its two enantiomers of 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane
with di-p-toluoyl-L-tartaric acid (L-DTTA) or di-p-toluoyl-D-tartaric acid
(D-DTTA) in a solution of alcohol or alcohol in water to give its salts, then resolved
the salts. This gives high enantiomer excess value, high yield which is more than
80% in total with normal separation and reversed separation.
Inventors:
SUN PIAOYANG (CN)
CHEN YONGJIANG (CN)
YU GUANGLIANG (CN)
CHEN YONGJIANG (CN)
YU GUANGLIANG (CN)
Application Number:
PCT/CN2008/001711
Publication Date:
May 22, 2009
Filing Date:
October 10, 2008
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SUN PIAOYANG (CN)
CHEN YONGJIANG (CN)
YU GUANGLIANG (CN)
SUN PIAOYANG (CN)
CHEN YONGJIANG (CN)
YU GUANGLIANG (CN)
International Classes:
C07C217/54; C07C213/08; C07D223/16
Foreign References:
| CN1699331A | 2005-11-23 | |||
| US5296482A | 1994-03-22 |
Other References:
See also references of EP 2213651A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (Tower E3 The Towers,Oriental Plaza, No.1, East Chang An Avenue,Dongcheng District, Beijing 8, CN)
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