Title:
RESOLUTION OF AGGRECAN GENE EXPRESSION USING SPECIFIC AND SELECTIVE ELECTRICAL AND ELECTROMAGNETIC SIGNALS
Document Type and Number:
WIPO Patent Application WO2004029210
Kind Code:
A3
Abstract:
Methods and devices for the regulation of aggrecan gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for aggrecan gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate aggrecan gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, and cartilage defects.
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Inventors:
BRIGHTON CARL T
Application Number:
PCT/US2003/030333
Publication Date:
February 10, 2005
Filing Date:
September 24, 2003
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
International Classes:
A61N1/32; A61N1/40; A61N2/04; C12N13/00; (IPC1-7): A61H39/00
Domestic Patent References:
| WO2001062336A1 | 2001-08-30 |
Other References:
See also references of EP 1560553A4
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