Title:
RESPIRATORY SYNCYTIAL VIRUS RECOMBINANT FUSION PROTEIN HAVING PRE-FUSION CONFORMATION, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067723
Kind Code:
A1
Abstract:
A respiratory syncytial virus subtype A (RSV-A) recombinant F protein, a polynucleotide, a nucleic acid construct, an expression vector, a host cell, a stabilized trimer formed by the recombinant F protein, an immunogenic composition comprising any one of the foregoing, and the use thereof in the preparation of a vaccine for preventing and/or treating respiratory syncytial virus infections. The RSV-A recombinant F protein comprises at least one specific epitope of pre-fusion F protein, can form a stable F protein trimer having pre-fusion conformation, and has stable expression, uniform form and increased yield. The formed F protein trimer has good immunogenicity and can stimulate the body to produce a high level of antibody titer.
Inventors:
YAN JINGHUA (CN)
HUANG QINGRUI (CN)
YANG MI (CN)
HUANG QINGRUI (CN)
YANG MI (CN)
Application Number:
PCT/CN2023/122155
Publication Date:
April 04, 2024
Filing Date:
September 27, 2023
Export Citation:
Assignee:
BEIJING BENEWILL TECH DEVELOPMENT CO LTD (CN)
International Classes:
C07K19/00; A61K39/155; A61P31/14; C07K14/135; C12N5/10; C12N15/62; C12N15/85
Domestic Patent References:
| WO2018109220A2 | 2018-06-21 |
Foreign References:
| CN105408348A | 2016-03-16 | |||
| CN112226450A | 2021-01-15 |
Attorney, Agent or Firm:
BEIJING YUEHE INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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