Title:
RESPONSE MARKER FOR ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY OF AGE-RELATED MACULAR DEGENERATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/002192
Kind Code:
A1
Abstract:
Provided in the present invention are a response marker for an anti-vascular endothelial growth factor therapy of age-related macular degeneration and the use thereof. Specifically, provided in the present invention is the use of an anti-VEGF responsive marker detection reagent in the preparation of a diagnostic reagent or a kit for judging the anti-VEGF responsiveness. Studies show that the anti-VEGF responsive marker can be used as a marker for judging the anti-VEGF responsiveness and evaluating the therapeutic effect of the anti-VEGF, and has a high sensitivity and specificity.
Inventors:
LIU KUN (CN)
SHEN YINCHEN (CN)
FANG JUNWEI (CN)
XIE LIPING (CN)
XU XUN (CN)
SHEN YINCHEN (CN)
FANG JUNWEI (CN)
XIE LIPING (CN)
XU XUN (CN)
Application Number:
PCT/CN2023/103376
Publication Date:
January 04, 2024
Filing Date:
June 28, 2023
Export Citation:
Assignee:
SHANGHAI FIRST PEOPLES HOSPITAL (CN)
International Classes:
G01N30/88
Domestic Patent References:
| WO2022101442A1 | 2022-05-19 | |||
| WO2020072004A2 | 2020-04-09 |
Foreign References:
| CN116027041A | 2023-04-28 |
Other References:
SHEN YINCHEN, WANG HANYING, XU XIAOYIN, CHEN CHONG, ZHU SHAOPIN, CHENG LU, FANG JUNWEI, LIU KUN, XU XUN: "Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy", FRONTIERS IN PHARMACOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 13, 19 September 2022 (2022-09-19), CH , pages 1 - 12, XP093122135, ISSN: 1663-9812, DOI: 10.3389/fphar.2022.991879
GAO YAN, TEO YI CHONG KELVIN, BEUERMAN ROGER W., WONG TIEN YIN, ZHOU LEI, CHEUNG CHUI MING GEMMY: "A serum metabolomics study of patients with nAMD in response to anti-VEGF therapy", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 10, no. 1, 28 January 2020 (2020-01-28), US , pages 1341, XP093122129, ISSN: 2045-2322, DOI: 10.1038/s41598-020-58346-3
GAO YAN, TEO YI CHONG KELVIN, BEUERMAN ROGER W., WONG TIEN YIN, ZHOU LEI, CHEUNG CHUI MING GEMMY: "A serum metabolomics study of patients with nAMD in response to anti-VEGF therapy", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 10, no. 1, 28 January 2020 (2020-01-28), US , pages 1341, XP093122129, ISSN: 2045-2322, DOI: 10.1038/s41598-020-58346-3
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF: