Title:
RESVERATROL MULTIMER HAVING SELECTIVE INHIBITORY ACTIVITY FOR HEPATITIS C VIRUS GENOME REPLICATION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/126129
Kind Code:
A3
Abstract:
The present invention relates to a resveratrol multimer having a selective inhibitory activity for hepatitis C virus genome replication, and a use thereof, and more particularly, to a resveratrol multimer having a selective inhibitory activity for hepatitis C virus genome replication, and a pharmaceutical composition for preventing or treating hepatitis C, containing the same. The resveratrol multimer according to the present invention has very low hepatotoxicity and a remarkable effect of selectively inhibiting hepatitis C virus genome replication, and thus is expected to be useful as an active ingredient of a pharmaceutical composition or a nutraceutical composition for preventing, alleviating or treating hepatitis C.
More Like This:
Inventors:
LEE CHOONG HO (KR)
YOON KEE DONG (KR)
HEO TAE-HWE (KR)
YOON KEE DONG (KR)
HEO TAE-HWE (KR)
Application Number:
PCT/KR2015/001577
Publication Date:
May 18, 2017
Filing Date:
February 16, 2015
Export Citation:
Assignee:
DONGGUK UNIV INDUSTRY-ACADEMIC COOP FOUND (KR)
THE CATHOLIC UNIV OF KOREA INDUSTRY-ACADEMIC COOP FOUND (KR)
THE CATHOLIC UNIV OF KOREA INDUSTRY-ACADEMIC COOP FOUND (KR)
International Classes:
C07D307/80; A61K31/05; A61K31/343
Foreign References:
| CN100584837C | 2010-01-27 |
Other References:
PFLIEGER, AUDE ET AL.: "Natural Stilbenoids Isolated from Grapevine Exhibiting Inhibitory Effects against HIV-1 Integrase and Eukaryote MOS1 Transposase in Vitro Activities", PLOS ONE, vol. 8, no. 11, 28 November 2013 (2013-11-28), pages 1 - 13, XP002729520
HUANG, YU-LING ET AL.: "+)-Vitisin A Inhibits Influenza A Virus-induced RANTES Production in A549 Alveolar Epithelial Cells through Interference with Akt and STAT1 Phosphorylation", PLANT A MEDICA, vol. 74, no. 2, February 2008 (2008-02-01), pages 156 - 162, XP018024472
CHEN, XIAOQING ET AL.: "Inhibition of Herpes Simplex Virus Infection by Oligomeric Stilbenoids through ROTS Generation", ANTIVIRAL RESEARCH, vol. 95, no. 1, July 2012 (2012-07-01), pages 30 - 36, XP028491142
HUANG, YU-LING ET AL.: "+)-Vitisin A Inhibits Influenza A Virus-induced RANTES Production in A549 Alveolar Epithelial Cells through Interference with Akt and STAT1 Phosphorylation", PLANT A MEDICA, vol. 74, no. 2, February 2008 (2008-02-01), pages 156 - 162, XP018024472
CHEN, XIAOQING ET AL.: "Inhibition of Herpes Simplex Virus Infection by Oligomeric Stilbenoids through ROTS Generation", ANTIVIRAL RESEARCH, vol. 95, no. 1, July 2012 (2012-07-01), pages 30 - 36, XP028491142
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
Download PDF:
Previous Patent: AGENT FOR CANCER THERAPY
Next Patent: METHOD AND DEVICE FOR SELECTING AND ALLOCATING TRANSMISSION BEAM INDEX HAVING PRIORITY
Next Patent: METHOD AND DEVICE FOR SELECTING AND ALLOCATING TRANSMISSION BEAM INDEX HAVING PRIORITY