Title:
RET INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2014/050781
Kind Code:
A1
Abstract:
A compound represented by general formula (I) (the symbols in the formula are as defined in the description), a salt thereof, or the like is a RET inhibitor or RET tyrosine kinase inhibitor that can be used as an agent for the prevention or treatment of disorders including cancers and cancer metastases having mutations in RET.
Inventors:
KODAMA TATSUSHI (JP)
SAKAMOTO HIROSHI (JP)
TSUKAGUCHI TOSHIYUKI (JP)
SAKAMOTO HIROSHI (JP)
TSUKAGUCHI TOSHIYUKI (JP)
Application Number:
PCT/JP2013/075621
Publication Date:
April 03, 2014
Filing Date:
September 24, 2013
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/5377; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07D401/04; C12N15/09; C12Q1/68
Domestic Patent References:
| WO2010143664A1 | 2010-12-16 | |||
| WO2012014795A1 | 2012-02-02 | |||
| WO2010143664A1 | 2010-12-16 | |||
| WO2012023597A1 | 2012-02-23 |
Foreign References:
| JP2012126711A | 2012-07-05 |
Other References:
SAKAMOTO H ET AL.: "CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.", CANCER CELL., vol. 19, no. 5, 17 May 2011 (2011-05-17), pages 679 - 690, XP055099130
KOHNO T ET AL.: "KIF5B-RET fusions in lung adenocarcinoma.", NAT MED., vol. 18, no. 3, 12 February 2012 (2012-02-12), pages 375 - 377, XP055145929
MOLOGNI L: "Development of RET kinase inhibitors for targeted cancer therapy.", CURR MED CHEM., vol. 18, no. 2, 2011, pages 162 - 175, XP055238903
SANG J ET AL.: "Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer.", CANCER DISCOV., vol. 3, no. 4, 26 March 2013 (2013-03-26), pages 430 - 443, XP008163109
SURGERY, vol. 141, 2007, pages 96 - 99
TRENDS, GENETICS, vol. 22, 2006, pages 627 - 636
EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 155, 2006, pages 645 - 653
NATURE MEDICINE, vol. 18, 2012, pages 378 - 381
J CLIN ONCOL, vol. 30, no. 35, 10 December 2012 (2012-12-10), pages 4352 - 9
CANCER DISCOV, vol. 3, no. 6, June 2013 (2013-06-01), pages 630 - 5
J CLIN ONCOL, vol. 30, 2012
CANCER CELL, vol. 19, no. 5, 2011, pages 679 - 690
NAT MED, vol. 18, no. 3, 12 February 2012 (2012-02-12), pages 375 - 7
TRENDS IN GENETICS, vol. 22, 2006, pages 627 - 636
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 7
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
NATURE MEDICINE, vol. 18, 2012, pages 382 - 384
NAT MED., vol. 18, no. 3, 12 February 2012 (2012-02-12), pages 378 - 81
CANCER DISCOV 2013 JUN, vol. 3, no. 6, June 2013 (2013-06-01), pages 630 - 5
RIKEN, J THORAC ONCOL, vol. 7, no. 12, December 2012 (2012-12-01), pages 1872 - 6
KOHNO T ET AL.: "KIF5B-RET fusions in lung adenocarcinoma.", NAT MED., vol. 18, no. 3, 12 February 2012 (2012-02-12), pages 375 - 377, XP055145929
MOLOGNI L: "Development of RET kinase inhibitors for targeted cancer therapy.", CURR MED CHEM., vol. 18, no. 2, 2011, pages 162 - 175, XP055238903
SANG J ET AL.: "Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer.", CANCER DISCOV., vol. 3, no. 4, 26 March 2013 (2013-03-26), pages 430 - 443, XP008163109
SURGERY, vol. 141, 2007, pages 96 - 99
TRENDS, GENETICS, vol. 22, 2006, pages 627 - 636
EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 155, 2006, pages 645 - 653
NATURE MEDICINE, vol. 18, 2012, pages 378 - 381
J CLIN ONCOL, vol. 30, no. 35, 10 December 2012 (2012-12-10), pages 4352 - 9
CANCER DISCOV, vol. 3, no. 6, June 2013 (2013-06-01), pages 630 - 5
J CLIN ONCOL, vol. 30, 2012
CANCER CELL, vol. 19, no. 5, 2011, pages 679 - 690
NAT MED, vol. 18, no. 3, 12 February 2012 (2012-02-12), pages 375 - 7
TRENDS IN GENETICS, vol. 22, 2006, pages 627 - 636
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 7
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 10
NATURE MEDICINE, vol. 18, 2012, pages 382 - 384
NAT MED., vol. 18, no. 3, 12 February 2012 (2012-02-12), pages 378 - 81
CANCER DISCOV 2013 JUN, vol. 3, no. 6, June 2013 (2013-06-01), pages 630 - 5
RIKEN, J THORAC ONCOL, vol. 7, no. 12, December 2012 (2012-12-01), pages 1872 - 6
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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