Title:
RETARGETING OF RAT PARVOVIRUS H-1PV TO CANCER CELLS THROUGH GENETIC ENGINEERING OF ITS CAPSID
Document Type and Number:
WIPO Patent Application WO/2012/052158
Kind Code:
A3
Abstract:
Described is a parvovirus, in particular a H-IPV, that can be genetically retargeted through modification of its capsid, which is useful in cancer therapy.
Inventors:
MARCHINI ANTONIO (DE)
EL-ANDALOUSSI NAZIM (DE)
ROMMELAERE JEAN (DE)
LEUCHS BARBARA (DE)
ALLAUME XAVIER (FR)
EL-ANDALOUSSI NAZIM (DE)
ROMMELAERE JEAN (DE)
LEUCHS BARBARA (DE)
ALLAUME XAVIER (FR)
Application Number:
PCT/EP2011/005229
Publication Date:
June 28, 2012
Filing Date:
October 18, 2011
Export Citation:
Assignee:
DEUTSCHES KREBSFORSCH (DE)
MARCHINI ANTONIO (DE)
EL-ANDALOUSSI NAZIM (DE)
ROMMELAERE JEAN (DE)
LEUCHS BARBARA (DE)
ALLAUME XAVIER (FR)
MARCHINI ANTONIO (DE)
EL-ANDALOUSSI NAZIM (DE)
ROMMELAERE JEAN (DE)
LEUCHS BARBARA (DE)
ALLAUME XAVIER (FR)
International Classes:
A61K35/76; A61K35/768; C07K14/015; C12N7/00
Domestic Patent References:
| WO2011138053A2 | 2011-11-10 | |||
| WO2003054197A2 | 2003-07-03 |
Other References:
LOPEZ-BUENO A ET AL: "Host-Selected Amino Acid Changes at the Sialic Acid Binding Pocket of the Parvovirus Capsid Modulate Cell Binding Affinity and Determine Virulence", JOURNAL OF VIROLOGY, vol. 80, no. 3, 13 January 2006 (2006-01-13), pages 1563 - 1573, XP055018781, ISSN: 0022-538X, DOI: 10.1128/JVI.80.3.1563-1573.2006
ROMMELAERE J ET AL: "Oncolytic parvoviruses as cancer therapeutics", CYTOKINE AND GROWTH FACTOR REVIEWS, ELSEVIER LTD, GB, vol. 21, no. 2-3, 1 April 2010 (2010-04-01), pages 185 - 195, XP027066640, ISSN: 1359-6101, [retrieved on 20100307], DOI: 10.1016/J.CYTOGFR.2010.02.011
ALLAUME X ET AL: "Retargeting of rat parvovirus H-1PV to cancer cells through genetic engineering of the viral capsid", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, 1 January 2012 (2012-01-01), pages 43PP, XP009156222, ISSN: 0022-538X, [retrieved on 20120118], DOI: 10.1128/JVI.06208-11
ROMMELAERE J ET AL: "Oncolytic parvoviruses as cancer therapeutics", CYTOKINE AND GROWTH FACTOR REVIEWS, ELSEVIER LTD, GB, vol. 21, no. 2-3, 1 April 2010 (2010-04-01), pages 185 - 195, XP027066640, ISSN: 1359-6101, [retrieved on 20100307], DOI: 10.1016/J.CYTOGFR.2010.02.011
ALLAUME X ET AL: "Retargeting of rat parvovirus H-1PV to cancer cells through genetic engineering of the viral capsid", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, 1 January 2012 (2012-01-01), pages 43PP, XP009156222, ISSN: 0022-538X, [retrieved on 20120118], DOI: 10.1128/JVI.06208-11
Attorney, Agent or Firm:
SCHÜSSLER, Andrea (Truderinger Str. 246, München, DE)
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