Title:
RETROVIRAL PROLIFERATION INHIBITOR, RETROVIRAL INFECTION PROPHYLACTIC DRUG CONTAINING SAME, AND RETROVIRAL INFECTION ONSET PROPHYLACTIC DRUG
Document Type and Number:
WIPO Patent Application WO/2018/225847
Kind Code:
A1
Abstract:
Provided is an agent that: inhibits the proliferation of retroviruses involved in retroviral infections such as acquired immunodeficiency syndrome, HTLV-1-associated myelopathy, and adult T cell leukemia; prevents retroviral infection; and prevents the onset of retroviral infection. A retroviral proliferation inhibitor characterized by containing metal-bonded fucoidan in which one or more metals selected from the group consisting of potassium, calcium, magnesium, zinc, and selenium are bonded to the sulfate groups of fucoidan, the zinc content in the metal-bonded fucoidan being 0.005% or higher per fucoidan 1 in terms of mass when the metal is zinc; a retroviral infection prophylactic drug containing the retroviral proliferation inhibitor; and a retroviral infection onset prophylactic drug.
Inventors:
IHA MASAHIKO (JP)
TOMORI MAKOTO (JP)
TANAKA YUETSU (JP)
FUKUSHIMA TAKUYA (JP)
MIYARA MEGUMI (JP)
IMAIZUMI NAOKI (JP)
TOMORI MAKOTO (JP)
TANAKA YUETSU (JP)
FUKUSHIMA TAKUYA (JP)
MIYARA MEGUMI (JP)
IMAIZUMI NAOKI (JP)
Application Number:
PCT/JP2018/021962
Publication Date:
December 13, 2018
Filing Date:
June 08, 2018
Export Citation:
Assignee:
SOUTH PRODUCT LTD (JP)
UNIV OF THE RYUKYUS (JP)
UNIV OF THE RYUKYUS (JP)
International Classes:
A61K31/737; A61K36/03; A61P31/14; A61P31/18; C08B37/00
Domestic Patent References:
| WO2017098653A1 | 2017-06-15 |
Foreign References:
| JPH10237103A | 1998-09-08 | |||
| JP2006083285A | 2006-03-30 | |||
| JP2007217410A | 2007-08-30 |
Other References:
DINESH, S. ET AL.: "In vitro anti-HIV-1 activity of fucoidan from Sargassum swartzii", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 82, 2016, pages 83 - 88, XP029357908, ISSN: 0141-8130
PROKOFJEVA, M. M. ET AL.: "Fucoidans as Potential Inhibitors of HIV-1", MARINE DRUGS, vol. 11, no. 8, 2013, pages 3000 - 3014, XP055561187, ISSN: 1660-3397
PROKOFJEVA, M. M. ET AL.: "Fucoidans as Potential Inhibitors of HIV-1", MARINE DRUGS, vol. 11, no. 8, 2013, pages 3000 - 3014, XP055561187, ISSN: 1660-3397
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY OF ONO & CO. (JP)
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