Title:
REVERSE HYDROXAMIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2003/022801
Kind Code:
A1
Abstract:
Reverse hydroxamic acid derivatives having specific structures represented by the general formula (Ia): (Ia) (wherein A represents hydrogen, etc.&semi Ar1 represents arylene, etc.&semi Ar2 represents optionally substituted aryl, heteroaryl, etc.&semi R1 represents hydrogen, alkyl, etc.&semi and R2a represents substituted cycloalkyl, heterocycloalkyl, etc.) and the general formula (I): (I) (wherein A, Ar1, ar2, and R1 are the same as defined above and R2 represents hydrogen, R2a, etc.) and salts of the derivatives. They have TNF−&agr converting enzyme (TACE) inhibitory activity.
Inventors:
SHIMANO MASANAO (JP)
KAMEI NORIYUKI (JP)
TANAKA TOMOHIRO (JP)
HARADA TATSUHIRO (JP)
HAINO MAKOTO (JP)
OKUYAMA AKIHIKO (JP)
ARAKAWA YOSHIO (JP)
MURAKAMI YOSHIKO (JP)
KAMEI NORIYUKI (JP)
TANAKA TOMOHIRO (JP)
HARADA TATSUHIRO (JP)
HAINO MAKOTO (JP)
OKUYAMA AKIHIKO (JP)
ARAKAWA YOSHIO (JP)
MURAKAMI YOSHIKO (JP)
Application Number:
PCT/JP2002/009036
Publication Date:
March 20, 2003
Filing Date:
September 05, 2002
Export Citation:
Assignee:
KAKEN PHARMA CO LTD (JP)
SHIMANO MASANAO (JP)
KAMEI NORIYUKI (JP)
TANAKA TOMOHIRO (JP)
HARADA TATSUHIRO (JP)
HAINO MAKOTO (JP)
OKUYAMA AKIHIKO (JP)
ARAKAWA YOSHIO (JP)
MURAKAMI YOSHIKO (JP)
SHIMANO MASANAO (JP)
KAMEI NORIYUKI (JP)
TANAKA TOMOHIRO (JP)
HARADA TATSUHIRO (JP)
HAINO MAKOTO (JP)
OKUYAMA AKIHIKO (JP)
ARAKAWA YOSHIO (JP)
MURAKAMI YOSHIKO (JP)
International Classes:
A61K31/165; A61K31/357; A61K31/435; A61K31/47; A61K31/4709; A61K31/496; A61K31/55; A61P1/14; A61P1/16; A61P3/10; A61P7/06; A61P9/00; A61P9/10; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P19/02; A61P19/08; A61P21/00; A61P29/00; A61P31/00; A61P35/00; A61P37/00; A61P37/08; A61P43/00; C07C317/28; C07D207/20; C07D211/70; C07D213/30; C07D213/42; C07D215/14; C07D277/14; C07D317/72; C07D319/06; C07D401/12; C07D405/12; C07D409/12; C07D417/12; C07D491/10; C07D491/113; (IPC1-7): C07C317/40; C07D213/30; C07D215/14; C07D317/72; C07D401/12; C07D405/12; C07D409/12; C07D417/12; C07D491/113; A61K31/165; A61K31/357; A61K31/435; A61K31/47; A61K31/4709; A61K31/496; A61K31/55; A61P1/14; A61P1/16; A61P3/10; A61P7/06; A61P9/00; A61P9/10; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P19/02; A61P19/08; A61P21/00; A61P4/25; A61P28/29; A61P29/00; A61P31/00; A61P35/00; A61P37/00; A61P37/08; A61P43/00
Domestic Patent References:
| WO2000044723A1 | 2000-08-03 | |||
| WO2000044713A1 | 2000-08-03 |
Other References:
See also references of EP 1431285A4
Attorney, Agent or Firm:
Asahina, Sohta (2-22 Tanimachi 2-chome Chuo-k, Osaka-shi Osaka, JP)
Download PDF: