REVERSIBLE CROSS-LINKED HYDROGELS

Title:

REVERSIBLE CROSS-LINKED HYDROGELS

Document Type and Number:

WIPO Patent Application WO2001040314

Kind Code:

A9

Abstract:

A hydrogel composition and methods of preparing and using the same are disclosed. The hydrogel composition comprises an oxidized polysaccharide, and a cross-linker having at least two functional cross-linking groups. The cross-linker reversibly cross-links the polysaccharide and is provided in an amount to provide dangling cross-linkers. The method of preparing a hydrogel comprises the steps of providing an oxidized polysaccharide, and providing a cross-linker having at least two functional cross-linking groups. The cross-linker is mixed with the polysaccharide at a concentration of the cross-linker sufficient to form a hydrogel wherein the cross-linker reversibly cross-links the polysaccharide and has dangling cross-linkers. The hydrogels are useful, for example, for tissue engineering, cell transplantation and drug delivery applications.

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Inventors:

LEE KUEN YONG (US)
MOONEY DAVID J (US)

Application Number:

PCT/US2000/032360

Publication Date:

August 15, 2002

Filing Date:

November 27, 2000

Export Citation:

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Assignee:

UNIV MICHIGAN (US)
LEE KUEN YONG (US)
MOONEY DAVID J (US)

International Classes:

A61L27/00; A61L15/16; A61L26/00; A61L27/20; C08J3/24; C08K5/00; C08L5/04; C08L101/00; (IPC1-7): C08B37/02; A61F2/02; C08B37/04; C08L5/04

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