Title:
REVERSIBLY-ACTIVATABLE ANTIBODY MIMETIC AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/135568
Kind Code:
A1
Abstract:
The present invention relates to the preparation of a reversibly-activatable antibody mimetic and the use thereof, and provides a fusion protein in which a first inactive fragment of an antibody mimetic is coupled with a stimulus-induced dimerization protein.
Inventors:
HEO WON DO (KR)
LEE YUN JU (KR)
YU DASEULI (KR)
PARK BYUNG OUK (KR)
LEE YUN JU (KR)
YU DASEULI (KR)
PARK BYUNG OUK (KR)
Application Number:
PCT/KR2016/015061
Publication Date:
August 10, 2017
Filing Date:
December 21, 2016
Export Citation:
Assignee:
INST BASIC SCIENCE (KR)
International Classes:
C07K16/00; A61K39/395; C12N15/62
Foreign References:
| US20100183516A1 | 2010-07-22 | |||
| KR20140031484A | 2014-03-13 |
Other References:
HUSSAIN ET AL.: "SNAP-tag Technology Mediates Site Specific Conjugation of Antibody Fragments with a Photosensitizer and Improves Target Specific Phototoxicity in Tumor Cells", BIOCONJUGATE CHEMISTRY, vol. 22, no. 12, 2011, pages 2487 - 2495, XP055300750
KAZANE ET AL.: "elf-assembled Antibody Multimers through Peptide Nucleic Acid Conjugation", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, 2013, pages 340 - 346, XP055076261
TASLIMI ET AL.: "An Optimized Optogenetic Clustering Tool for Probing Protein Interaction and Function", NATURE COMMUNICATIONS, vol. 5, no. 4925, 2014, pages 1 - 9, XP055405788
KAZANE ET AL.: "elf-assembled Antibody Multimers through Peptide Nucleic Acid Conjugation", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, 2013, pages 340 - 346, XP055076261
TASLIMI ET AL.: "An Optimized Optogenetic Clustering Tool for Probing Protein Interaction and Function", NATURE COMMUNICATIONS, vol. 5, no. 4925, 2014, pages 1 - 9, XP055405788
Attorney, Agent or Firm:
HAN, Yun Ho (KR)
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