Title:
REVERSIBLY CROSSLINKED MICELLE SYSTEMS
Document Type and Number:
WIPO Patent Application WO/2012/158622
Kind Code:
A3
Abstract:
The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.
Inventors:
LAM KIT S (US)
LI YUANPEI (US)
LUO JUNTAO (US)
XIAO KAI (US)
LI YUANPEI (US)
LUO JUNTAO (US)
XIAO KAI (US)
Application Number:
PCT/US2012/037794
Publication Date:
March 28, 2013
Filing Date:
May 14, 2012
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
LAM KIT S (US)
LI YUANPEI (US)
LUO JUNTAO (US)
XIAO KAI (US)
LAM KIT S (US)
LI YUANPEI (US)
LUO JUNTAO (US)
XIAO KAI (US)
International Classes:
C08G83/00; A61K9/127; A61K47/30; A61K47/48; C08G65/00; C08L101/02
Domestic Patent References:
| WO2010039496A2 | 2010-04-08 |
Foreign References:
| US20060127310A1 | 2006-06-15 | |||
| US20080188399A1 | 2008-08-07 |
Other References:
LI, YUANPEI ET AL.: "Well-defined, reversible disulfide cross-linked micelles for on-demand paclitaxel delivery", BIOMATERIALS, vol. 32, no. 27, 30 September 2011 (2011-09-30), pages 6633 - 6645, XP028254253
LI, YUANPEI ET AL.: "Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols", ANGEWANDTE CHEMIE, vol. 124, no. 12, 19 March 2012 (2012-03-19), pages 2918 - 2923, XP055133723
LI, YUANPEI ET AL.: "Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis-Diols", ANGEWANDTE CHEMIE, vol. 124, no. 12, 19 March 2012 (2012-03-19), pages 2918 - 2923, XP055133723
Attorney, Agent or Firm:
TRIMBLE, Alexander R. et al. (Two Embarcadero Center 8th Floo, San Francisco California, US)
Download PDF:
Previous Patent: SECURE AND SCALABLE MAPPING OF HUMAN SEQUENCING READS ON HYBRID CLOUDS
Next Patent: CONSUMER ALARM WITH QUIET BUTTON
Next Patent: CONSUMER ALARM WITH QUIET BUTTON