Title:
REVERSING AGENT FOR ANTICOAGULANTS
Document Type and Number:
WIPO Patent Application WO/2012/043577
Kind Code:
A1
Abstract:
The problem addressed by the present invention is the provision of: a reversing agent that reverses the anticoagulant effects of an FXa inhibitor; and/or a reversal method using said reversing agent. [Solution] A reversing agent for an oral anticoagulant, said reversing agent causing clotting. Said clotting agent is one or more of the following: a dried complex that has the effect of circumventing antibodies for a human blood coagulation factor; a dried complex of human blood coagulation factor IX; and recombinant activated factor VII.
Inventors:
MORISHIMA YOSHIYUKI
Application Number:
PCT/JP2011/072106
Publication Date:
April 05, 2012
Filing Date:
September 27, 2011
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
MORISHIMA YOSHIYUKI
MORISHIMA YOSHIYUKI
International Classes:
A61K38/46; A61P7/04; A61P39/02; A61K31/444
Other References:
GRUBER,A. ET AL.: "Potential of Activated Prothrombin Complex Concentrate and Activated Factor VII to Reverse the Anticoagulant Effects of Rivaroxaban in Primates. Abstr. 3825", BLOOD, vol. 112, 2008
BIJSTERVELD,N.R. ET AL.: "Recombinant factor VIIa reverses the anticoagulant effect of the long- acting pentasaccharide idraparinux in healthy volunteers", BRITISH JOURNAL OF HAEMATOLOGY, vol. 124, no. 5, 2004, pages 653 - 658
BIJSTERVELD,N.R. ET AL.: "Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers", CIRCULATION, vol. 106, no. 20, 2002, pages 2550 - 2554
TENPU BUNSHO ET AL., FEIBA CHUSHAYO 500, FEIBA CHUSHAYO 1000, no. 13, 2008
TENPU BUNSHO, CHUSHAYO NOVOSEVEN (R) 1.2MG, CHUSHAYO NOVOSEVEN (R) 4,8MG, no. 10, March 2010 (2010-03-01)
TENPU BUNSHO, PPSB (R)-BT JOCHUYO 200 TAN'I 'NICHIYAKU', PPSB (R)-BT JOCHUYO 500 TAN'I 'NICHIYAKU', no. 14, 2009
FURUGOHRI,T. ET AL.: "DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles", J THROMB HAEMOST, vol. 6, no. 9, 2008, pages 1542 - 1549, XP002659799, DOI: doi:10.1111/J.1538-7836.2008.03064.X
MORISHIMA,Y. ET AL.: "Anti-Inhibitor Coagulant Complex, Prothrombin Complex Concentrate, and Recombinant Factor VIIa Reverse Prothrombin Time Prolonged by Edoxaban In Human Plasma", BLOOD, vol. 116, November 2010 (2010-11-01)
EERENBERG,E.S. ET AL.: "Prothrombin Complex Concentrate Reverses the Anticoagulant Effect of Rivaroxaban In Healthy Volunteers", BLOOD, vol. 116, November 2010 (2010-11-01)
BIJSTERVELD,N.R. ET AL.: "Recombinant factor VIIa reverses the anticoagulant effect of the long- acting pentasaccharide idraparinux in healthy volunteers", BRITISH JOURNAL OF HAEMATOLOGY, vol. 124, no. 5, 2004, pages 653 - 658
BIJSTERVELD,N.R. ET AL.: "Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers", CIRCULATION, vol. 106, no. 20, 2002, pages 2550 - 2554
TENPU BUNSHO ET AL., FEIBA CHUSHAYO 500, FEIBA CHUSHAYO 1000, no. 13, 2008
TENPU BUNSHO, CHUSHAYO NOVOSEVEN (R) 1.2MG, CHUSHAYO NOVOSEVEN (R) 4,8MG, no. 10, March 2010 (2010-03-01)
TENPU BUNSHO, PPSB (R)-BT JOCHUYO 200 TAN'I 'NICHIYAKU', PPSB (R)-BT JOCHUYO 500 TAN'I 'NICHIYAKU', no. 14, 2009
FURUGOHRI,T. ET AL.: "DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles", J THROMB HAEMOST, vol. 6, no. 9, 2008, pages 1542 - 1549, XP002659799, DOI: doi:10.1111/J.1538-7836.2008.03064.X
MORISHIMA,Y. ET AL.: "Anti-Inhibitor Coagulant Complex, Prothrombin Complex Concentrate, and Recombinant Factor VIIa Reverse Prothrombin Time Prolonged by Edoxaban In Human Plasma", BLOOD, vol. 116, November 2010 (2010-11-01)
EERENBERG,E.S. ET AL.: "Prothrombin Complex Concentrate Reverses the Anticoagulant Effect of Rivaroxaban In Healthy Volunteers", BLOOD, vol. 116, November 2010 (2010-11-01)
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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