RFB RETROVIRUS GENOME

WIPO Patent Application WO/1995/027063

A2

The invention concerns the complete gene sequence of the RFB provirus genome. According to the invention, RFB retrovirus and other osteoinductive retroviruses associated therewith are used to develop a therapeutic agent for treating bone diseases, in particular for inducing bone regeneration. The coding areas of the RFB retrovirus are identified as the genome sections responsible for bone regeneration.

SCHMIDT JOERG (DE)
GIMBEL WOLFGANG (DE)
STRAUSS PAUL-GUENTER (DE)
ERFLE VOLKER (DE)
PEDERSEN FINN SKOU (DK)
PEDERSEN LENE (DK)
OESTERGAARD METTE (DK)

PCT/EP1995/001234

October 12, 1995

April 05, 1995

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GSF FORSCHUNGSZENTRUM UMWELT (DE)
SCHMIDT JOERG (DE)
GIMBEL WOLFGANG (DE)
STRAUSS PAUL GUENTER (DE)
ERFLE VOLKER (DE)
PEDERSEN FINN SKOU (DK)
PEDERSEN LENE (DK)
OESTERGAARD METTE (DK)

C07K14/15; C12N15/48; A61K38/00; (IPC1-7): C12N15/48; C07K14/15; C12N5/10; C12N15/63; C12N15/79

WO1994005780A1

1994-03-17

EP0572737A2

1993-12-08

JOURNAL OF VIROLOGY, Bd.55, Nr.3, Seiten 521 - 526 A. DUSTY MILLER ET AL. 'Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity'
JOURNAL OF VIROLOGY, Bd.66, Nr.10, Seiten 6186 - 6190 L. PEDERSEN ET AL. 'Molecular Cloning of Osteoma-Inducing replication Competent Murine Leukemia Viruses from the RFB Osteoma Virus Stock'

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