Title:
RGD POLYPEPTIDE GRAFTED POLY (GLYCOLIC ACID-L-LYSINE-L-LACTIC ACID) / β-TRICALCIUM PHOSPHATE COMPOSITE MATERIAL AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/006252
Kind Code:
A1
Abstract:
An RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) / β-tricalcium phosphate
composite material is made up of β-tricalcium phosphate particles and
RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) with mass
ratio of 1:10~1:100, wherein the β-tricalcium phosphate particles are
uniformly dispersed in the RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid)
matrix. The preparation method includes reacting poly (glycolic acid-L-lysine-L-lactic acid)
with GRGDY short peptide (glycin-arginine-glycin-aspartic acid-tyrosine sequence)
to obtain RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid),
and mixing the obtained RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid)
with β-tricalcium phosphate particles. The composite material has favorite
biocompatibility, cellualar affinity, biodegradability and mechanical property,
and can avoid aseptic necrosis of tissues, which may be used as nerve guide or porous
bone scaffold for repairing nerve tissue and bone tissue.
Inventors:
LI SHIPU (CN)
HAN YINGCHAO (CN)
YAN YUHUA (CN)
WAN TAO (CN)
WANG XINYU (CN)
YUAN LIN (CN)
DAI HONGLIAN (CN)
YAN QIONGJIAO (CN)
HAN YINGCHAO (CN)
YAN YUHUA (CN)
WAN TAO (CN)
WANG XINYU (CN)
YUAN LIN (CN)
DAI HONGLIAN (CN)
YAN QIONGJIAO (CN)
Application Number:
PCT/CN2006/001863
Publication Date:
January 17, 2008
Filing Date:
July 26, 2006
Export Citation:
Assignee:
UNIV WUHAN TECH (CN)
LI SHIPU (CN)
HAN YINGCHAO (CN)
YAN YUHUA (CN)
WAN TAO (CN)
WANG XINYU (CN)
YUAN LIN (CN)
DAI HONGLIAN (CN)
YAN QIONGJIAO (CN)
LI SHIPU (CN)
HAN YINGCHAO (CN)
YAN YUHUA (CN)
WAN TAO (CN)
WANG XINYU (CN)
YUAN LIN (CN)
DAI HONGLIAN (CN)
YAN QIONGJIAO (CN)
International Classes:
A61L27/46; A61F2/04; A61L27/54; C08L67/04
Domestic Patent References:
| WO2004073563A2 | 2004-09-02 |
Foreign References:
| US20050161857A1 | 2005-07-28 | |||
| US20050079470A1 | 2005-04-14 | |||
| US20020022883A1 | 2002-02-21 |
Other References:
LIU G. ET AL.: "Preparation of Poly (lactic acid-co-glycolic acid) biomimetic biodegradable polymer scaffolds", CHIN. J. EXP. SURG., vol. 21, no. 4, April 2004 (2004-04-01), pages 461 - 463
See also references of EP 2039377A4
See also references of EP 2039377A4
Attorney, Agent or Firm:
WUHAN KAIYUAN PATENT AGENT LTD. (Wuhan, Hubei 6, CN)
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