Title:
RHO KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2014/055996
Kind Code:
A3
Abstract:
The invention relates to inhibitors of ROCKl and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCKl and/or ROCK2.
Inventors:
POYUROVSKY MASHA (US)
KIM JEAN (US)
LIU KEVIN (US)
ZANIN-ZHOROV ALEXANDRA (US)
KIM JEAN (US)
LIU KEVIN (US)
ZANIN-ZHOROV ALEXANDRA (US)
Application Number:
PCT/US2013/063752
Publication Date:
June 19, 2014
Filing Date:
October 07, 2013
Export Citation:
Assignee:
KADMON CORP LLC (US)
International Classes:
A61K31/506; A61K31/416; C07D239/42
Foreign References:
| US20090306086A1 | 2009-12-10 | |||
| US20100144707A1 | 2010-06-10 | |||
| US20040002508A1 | 2004-01-01 |
Other References:
JIANG ET AL.: "Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice", INT. J. MOL. SCI., vol. 13, 4 December 2012 (2012-12-04), pages 8293 - 8307, XP055253655
BISWAS ET AL.: "Aberrant ROCK activation promotes the development of type I diabetes in NOD mice", CELL IMMUNOL., vol. 266, no. 2, 1 January 2011 (2011-01-01), pages 111 - 115, XP027554660
BISWAS ET AL.: "Aberrant ROCK activation promotes the development of type I diabetes in NOD mice", CELL IMMUNOL., vol. 266, no. 2, 1 January 2011 (2011-01-01), pages 111 - 115, XP027554660
Attorney, Agent or Firm:
SOMERVILLE, Deborah, A. et al. (One BroadwayNew York, NY, US)
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