Title:
RIFAXIMIN DERIVATIVE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/112809
Kind Code:
A3
Abstract:
25-desacetyl rifaximin or a pharmaceutically acceptable salt thereof is provided. Methods of treatment of bowl related disorders using isolated and/or purified 25-desacetyl rifaximin or a pharmaceutically acceptable salt thereof are also provided. Bowel related disorders, include, for example, Irritable bowel syndrome, travelers' diarrhea, small intestinal, bacterial overgrowth, Crohn's disease, chronic pancreatitis, pancreatic insufficiency, hepatic encephalopathy, pouchitis, enteritis and colitis (including, ulcerative colitis) and other related conditions. In certain embodiments, the 25-desacetyl rifaximin is isolated and/or purified.
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Inventors:
GOLDEN PAM (US)
KABIR MOHAMMED A (US)
VISCOMI GIUSEPPE CLAUDIO (IT)
CAMPANA MANUELA (IT)
CONFORTINI DONATELLA (IT)
BARBANTI MIRIAM (IT)
KABIR MOHAMMED A (US)
VISCOMI GIUSEPPE CLAUDIO (IT)
CAMPANA MANUELA (IT)
CONFORTINI DONATELLA (IT)
BARBANTI MIRIAM (IT)
Application Number:
PCT/US2013/023110
Publication Date:
July 31, 2014
Filing Date:
January 25, 2013
Export Citation:
Assignee:
SALIX PHARMACEUTICALS LTD (US)
ALFA WASSERMANN SPA (IT)
ALFA WASSERMANN SPA (IT)
International Classes:
C07D267/22; C07D213/00; C07D281/18
Foreign References:
| US20090028940A1 | 2009-01-29 | |||
| US4188321A | 1980-02-12 | |||
| US20090093415A1 | 2009-04-09 | |||
| US20030009022A1 | 2003-01-09 | |||
| US20090082558A1 | 2009-03-26 | |||
| US20120077835A1 | 2012-03-29 | |||
| US20120214833A1 | 2012-08-23 | |||
| US20110065740A1 | 2011-03-17 | |||
| US20110294726A1 | 2011-12-01 | |||
| US20110178113A1 | 2011-07-21 | |||
| US20110105550A1 | 2011-05-05 | |||
| US20080009487A1 | 2008-01-10 |
Other References:
DI STEFANO ET AL.: "Systemic Absorption of Rifamycin SV MMX Administered as Modified-Release Tablets in Healthy Volunteers.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 55, no. 5, 2011, pages 2122 - 2128, XP055156711
ARISTOFF ET AL.: "Rifamycins-Obstacles and opportunlties.", TUBERCULOSIS, vol. 90, 2010, pages 94 - 118, XP026994979
SELVA ET AL.: "Rifamycins, Antibacterial Antibiotics and Their New Applications.", ANALOGUE-BASED DRUG DISCOVERY II, 2010, pages 173 - 187, XP055156808
RASTOGI ET AL.: "Activity of rifapentine and its metabolite 25.O-desacetylrifapentine compared with rifampicin and rifabtin against Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis and M.bovis BCG.", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 46, 2000, pages 565 - 570, XP055156811
ARISTOFF ET AL.: "Rifamycins-Obstacles and opportunlties.", TUBERCULOSIS, vol. 90, 2010, pages 94 - 118, XP026994979
SELVA ET AL.: "Rifamycins, Antibacterial Antibiotics and Their New Applications.", ANALOGUE-BASED DRUG DISCOVERY II, 2010, pages 173 - 187, XP055156808
RASTOGI ET AL.: "Activity of rifapentine and its metabolite 25.O-desacetylrifapentine compared with rifampicin and rifabtin against Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis and M.bovis BCG.", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 46, 2000, pages 565 - 570, XP055156811
Attorney, Agent or Firm:
SPARKS, Jonathan M. et al. (265 Franklin StreetBoston, MA, US)
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