Title:
RING-SHAPED CARDIAC MUSCLE CELL MASS
Document Type and Number:
WIPO Patent Application WO/2018/124210
Kind Code:
A1
Abstract:
The present disclosure provides a ring-shaped cardiac muscle cell mass in which an electric signal or a calcium signal can progress while circulating therethrough. Also provided is a method for producing the ring-shaped cardiac muscle cell mass, said method comprising a step of culturing cardiac muscle cells induced from pluripotent stem cells in a culture vessel having a protruded part formed at the inside bottom thereof. Also provided is a culture vessel having a protruded part formed at the inside bottom thereof. Also provided are: a method for assessing the cardiotoxicity of a candidate substance for a medicine and a method for screening for a therapeutic agent for a heart disease, in each of which the ring-shaped cardiac muscle cell mass is used; and a kit for the method, which includes the ring-shaped cardiac muscle cell mass.
More Like This:
| WO/2004/101743 | THREE DIMENSIONAL CELL CULTURES IN A MICROSCALE FLUID HANDLING SYSTEM |
| WO/2021/097538 | BONE FORMATION |
Inventors:
LIU LI (JP)
LI JUNJUN (JP)
LI JUNJUN (JP)
Application Number:
PCT/JP2017/047027
Publication Date:
July 05, 2018
Filing Date:
December 27, 2017
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12N5/00; A61P9/00; C12M3/00; C12N5/077; C12N5/10; C12Q1/02
Domestic Patent References:
| WO2015182765A1 | 2015-12-03 |
Foreign References:
| JP2016504022A | 2016-02-12 | |||
| JP2004500093A | 2004-01-08 |
Other References:
GOSSMANN, M. ET AL.: "Mechano-Pharmacological Characterization of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 38, no. 3, 17 March 2016 (2016-03-17), pages 1182 - 1198, XP055515227
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Download PDF:
Previous Patent: METHOD FOR CODING DIGITAL INK AND METHOD FOR DECODING SAME
Next Patent: SUBSTRATE PROCESSING DEVICE AND SUBSTRATE PROCESSING METHOD
Next Patent: SUBSTRATE PROCESSING DEVICE AND SUBSTRATE PROCESSING METHOD