Title:
RNA REACTION TYPE FLUORESCENT PROBE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/060196
Kind Code:
A1
Abstract:
Provided are an RNA reaction type fluorescent probe (9), a preparation method therefor, and use thereof in tumor imaging and treatment. After the probe (9) is responded by an ALP enzyme, the fluorescence thereof is enhanced, and a photo-acoustic effect at 685 nm is also enhanced. Meanwhile, the probe (9) can be subjected to a cross-linking reaction with cytoplasmic RNA under the irradiation of red light after being responded by the ALP enzyme, such that the retention time of the probe (9) in a tumor cell is prolonged, and tumor imaging in a long window period is realized. The cross-linking reaction causes damage to mitochondria, such that serious tumor cell apoptosis is caused, and therefore tumor growth is inhibited. The probe (9) not only can perform long-window-period near-infrared and photo-acoustic bimodal imaging on a tumor, but also can inhibit tumor growth and realize integration of tumor diagnosis and treatment.
Inventors:
SHI HAIBIN (CN)
FANG JING (CN)
FANG JING (CN)
Application Number:
PCT/CN2022/120856
Publication Date:
March 28, 2024
Filing Date:
September 23, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07K7/64; A61K49/00; C07K1/02; C09K11/06
Foreign References:
| CN112592386A | 2021-04-02 | |||
| CN106753341A | 2017-05-31 | |||
| CN114656459A | 2022-06-24 | |||
| US20190321495A1 | 2019-10-24 |
Other References:
SHUYUE YE, FENG YALI; SHI HAIBIN: "Recent Advances in Smart Molecular Probes for Tumor Theranostics", MATERIALS REPORTS, vol. 36, no. 3, 30 January 2022 (2022-01-30), pages 21120202 - 21120202-15, XP093149398
FANG JING, ZHAO YAN, WANG ANNA, ZHANG YUQI, CUI CHAOXIANG, YE SHUYUE, MAO QIULIAN, FENG YALI, LI JIACHEN, XU CHENJIE, SHI HAIBIN: "In Vivo Quantitative Assessment of a Radiation Dose Based on Ratiometric Photoacoustic Imaging of Tumor Apoptosis", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 94, no. 12, 29 March 2022 (2022-03-29), US , pages 5149 - 5158, XP093149383, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.2c00098
FANG JING, ZHAO YAN, WANG ANNA, ZHANG YUQI, CUI CHAOXIANG, YE SHUYUE, MAO QIULIAN, FENG YALI, LI JIACHEN, XU CHENJIE, SHI HAIBIN: "In Vivo Quantitative Assessment of a Radiation Dose Based on Ratiometric Photoacoustic Imaging of Tumor Apoptosis", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 94, no. 12, 29 March 2022 (2022-03-29), US , pages 5149 - 5158, XP093149383, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.2c00098
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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