Title:
ROBO1 CAR-NK CELL CARRYING SUICIDE GENE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/187016
Kind Code:
A1
Abstract:
Provided is a ROBO1 CAR-NK cell carrying suicide gene, a preparation method therefor and application thereof. In order to increase the safety and controllability of CAR-NK therapy, on the basis of the present ROBO1 CAR-NK cell, a suicide gene switch original is integrated into a genome by means of a lentiviral transfection technology to form a CAR-NK carrying suicide gene.
Inventors:
HAN KUNKUN (CN)
FU JIANMIN (CN)
ZHOU MIN (CN)
ZENG FANJUN (CN)
WANG QIANG (CN)
LI HUASHUN (CN)
FU JIANMIN (CN)
ZHOU MIN (CN)
ZENG FANJUN (CN)
WANG QIANG (CN)
LI HUASHUN (CN)
Application Number:
PCT/CN2020/077582
Publication Date:
September 24, 2020
Filing Date:
March 03, 2020
Export Citation:
Assignee:
ASCLEPIUS SUZHOU TECH COMPANY GROUP CO LTD (CN)
International Classes:
C12N15/62; A61K35/17; A61P35/00; C07K19/00; C12N5/10; C12N15/867
Foreign References:
| CN108977453A | 2018-12-11 | |||
| CN107365798A | 2017-11-21 | |||
| US20130071414A1 | 2013-03-21 |
Other References:
See also references of EP 3940076A4
Attorney, Agent or Firm:
BEIJING BRIGHT IP AGENCY CO., LTD. (CN)
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