Title:
ROR1-POSITIVE MESENCHYMAL STEM CELL-CONTAINING PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASE ASSOCIATED WITH FIBROSIS, METHOD FOR PREPARING SAME, AND METHOD FOR PREVENTING OR TREATING DISEASE ASSOCIATED WITH FIBROSIS USING ROR1-POSITIVE MESENCHYMAL STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2018/164228
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide the following: novel mesenchymal stem cells having an excellent therapeutic effect on various diseases, particularly diseases associated with fibrosis; and a pharmaceutical composition containing such mesenchymal stem cells. The present invention is a therapeutic agent for fibrosis that contains ROR1-positive mesenchymal stem cells and/or a culture supernatant thereof and that is for preventing or treating a disease associated with fibrosis. The mesenchymal stem cells are CD29-, CD73-, CD90-, CD105-, and CD166-positive and are preferably derived from the umbilical cord or fat. In addition, the abovementioned disease associated with fibrosis is preferably a liver disease, a lung disease, a kidney disease, or a heart disease.
Inventors:
HASEGAWA HIKARI (JP)
YUMOTO MASAYO (JP)
IKEYAMA YOSHIFUMI (JP)
NISHIDA HIROYUKI (JP)
TSUDA TOMOHIRO (JP)
UNO EIKO (JP)
SUDA KAZUMA (JP)
YOSHINO MIHOKO (JP)
NGO XUAN TRUNG (JP)
YUMOTO MASAYO (JP)
IKEYAMA YOSHIFUMI (JP)
NISHIDA HIROYUKI (JP)
TSUDA TOMOHIRO (JP)
UNO EIKO (JP)
SUDA KAZUMA (JP)
YOSHINO MIHOKO (JP)
NGO XUAN TRUNG (JP)
Application Number:
PCT/JP2018/009019
Publication Date:
September 13, 2018
Filing Date:
March 08, 2018
Export Citation:
Assignee:
ROHTO PHARMA (JP)
International Classes:
A61K35/28; A61K35/51; A61P1/16; A61P9/04; A61P9/10; A61P11/00; A61P13/12
Domestic Patent References:
| WO2016136986A1 | 2016-09-01 | |||
| WO2017038784A1 | 2017-03-09 |
Foreign References:
| JP2009519978A | 2009-05-21 | |||
| JP2008525489A | 2008-07-17 | |||
| JP2007528705A | 2007-10-18 | |||
| JP2012157263A | 2012-08-23 | |||
| JP2012508733A | 2012-04-12 |
Other References:
CAI, SHI-XIA ET AL.: "Activation of Wnt/ beta -catenin signalling promotes mesenchymal stem cells to repair injured alveolar epithelium induced by lipopolysaccharide in mice", STEM CELL RES. THER., vol. 6, no. 65, 11 April 2015 (2015-04-11), XP021215867
SUSAN E. SAMARAS ET AL., THE AMERICAN JOURNAL OF PATHOLOGY, vol. 185, no. 1, January 2015 (2015-01-01)
INGA MANNAERTS ET AL., JOURNAL OF HEPATOLOGY, 2015
KARINNA ALMODOVAR-GARCIA ET AL., MCB, 2014
ATLA, vol. 42, 2014, pages 235 - 243
See also references of EP 3593809A4
SUSAN E. SAMARAS ET AL., THE AMERICAN JOURNAL OF PATHOLOGY, vol. 185, no. 1, January 2015 (2015-01-01)
INGA MANNAERTS ET AL., JOURNAL OF HEPATOLOGY, 2015
KARINNA ALMODOVAR-GARCIA ET AL., MCB, 2014
ATLA, vol. 42, 2014, pages 235 - 243
See also references of EP 3593809A4
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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