Title:
ROS-RESPONSIVE CAPTOPRIL-CINNAMALDEHYDE PRODRUGS AND COMPOSITIONS AND METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/284611
Kind Code:
A1
Abstract:
ROS-responsive prodrugs and methods of making thereof are disclosed. These prodrugs can contain two captopril moieties and one cinnamaldehyde moiety that are linked by a thioacetal linking moiety; upon cleavage of the thioacetal linking moiety by ROS, the prodrugs can release two captopril or captopril derivatives and one cinnamaldehyde or cinnamaldehyde derivative. Pharmaceutical formulations in a unit dosage form suitable for the delivery of the prodrugs to a subject in need thereof are disclosed. The pharmaceutical formulations may include one or more additional anti-inflammatory active agents in their free form. The pharmaceutical formulation can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. Methods for preventing or treating an inflammatory disease or disorder, or treating or ameliorating one or more symptoms associated with an inflammatory disease or disorder in a subject are also disclosed. The inflammatory disease or disorder can be rheumatoid arthritis.
Inventors:
WANG WEIPING (CN)
ZHANG YAMING (CN)
ZHANG YAMING (CN)
Application Number:
PCT/CN2022/104160
Publication Date:
January 19, 2023
Filing Date:
July 06, 2022
Export Citation:
Assignee:
UNIV HONG KONG (CN)
International Classes:
C07D207/06; A61K31/40; A61P9/12
Foreign References:
| CN112206207A | 2021-01-12 | |||
| CN108623807A | 2018-10-09 | |||
| US5917055A | 1999-06-29 |
Other References:
DATABASE REGISTRY STN; ANONYMOUS : "Benzene, [(1E)-3,3-bis(butylthio)-1-propen-1-yl]-", XP093024782
YU YEFEI, CHEN JIFENG, LIU SHUANG, CHENG DU: "ROS-responsive organosilica nanocarrier for the targeted delivery of metformin against cancer with the synergistic effect of hypoglycemia", JOURNAL OF MATERIALS CHEMISTRY. B, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 9, no. 30, 4 August 2021 (2021-08-04), GB , pages 6044 - 6055, XP093024783, ISSN: 2050-750X, DOI: 10.1039/D1TB01143J
YU YEFEI, CHEN JIFENG, LIU SHUANG, CHENG DU: "ROS-responsive organosilica nanocarrier for the targeted delivery of metformin against cancer with the synergistic effect of hypoglycemia", JOURNAL OF MATERIALS CHEMISTRY. B, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 9, no. 30, 4 August 2021 (2021-08-04), GB , pages 6044 - 6055, XP093024783, ISSN: 2050-750X, DOI: 10.1039/D1TB01143J
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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