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Title:
ROTIGOTINE BEHENATE, AND MANUFACTURING METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/014277
Kind Code:
A1
Abstract:
The present invention relates to a rotigotine behenate and a manufacturing method and application thereof, and provides a method for manufacturing the rotigotine behenate and an application of the rotigotine behenate in treating a disease related to a dopamine receptor. The structure of the rotigotine behenate is represented by formula I. The fluctuations of plasma concentration of the rotigotine behenate in vivo are small. The rotigotine behenate can maintain an effective plasma concentration for an extended period, has high bioavailability, and can achieve the effect of extended, effective, and stable release.

Inventors:
YANG MINA (CN)
JIANG YONGTAO (CN)
MENG YING (CN)
WANG TAO (CN)
XU QIAN QIAN (CN)
SHAO XIN (CN)
SHA CHUNJIE (CN)
Application Number:
PCT/CN2016/090803
Publication Date:
January 25, 2018
Filing Date:
July 21, 2016
Export Citation:
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Assignee:
SHANDONG LUYE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D333/10; A61K31/381; A61P25/16
Domestic Patent References:
WO2016014242A12016-01-28
WO2013168033A12013-11-14
Other References:
See also references of EP 3489227A4
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