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Title:
RUTHENIUM COMPOUND, DIAMINE COMPOUND, AND PROCESS FOR PRODUCING $g(b)-AMINO -ALCOHOL
Document Type and Number:
WIPO Patent Application WO/2002/055477
Kind Code:
A1
Abstract:
A ruthenium (Ru) compound which is useful as a catalyst for asymmetric hydrogenation; a diamine ligand; and a process for highly stereoselectively producing an optically active alcohol in high yield. The process comprises using a ruthenium compound represented by the general formula (1): Ru(Px)¿n1?[DIAMINE](X)(Y) {wherein Px represents a phosphine ligand; DIAMINE represents an optically active diamine represented by the general formula (2): R?1¿R?2¿C*(NHR?5¿)-(A)-R?3¿R?4¿C*(NH¿2?) [wherein R?1¿ to R?4¿ each independently represents hydrogen, optionally substituted alkyl, etc.; A represents optionally substituted C¿1-3? alkylene optionally containing an ether bond, optionally substituted C¿3-8? cycloalkylene, etc.; R?5¿ represents optionally substituted alkyl, optionally substituted aralkyl, or optionally substituted aryl; and C* represents asymmetric carbon]; X and Y each independently represents an anion; and n1 is an integer of 1 or 2} as a catalyst for asymmetric hydrogenation to produce a $g(b)-amino alcohol from an $g(a)-aminocarbonyl compound.

Inventors:
SATO DAISUKE (JP)
OOKA HIROHITO (JP)
INOUE TSUTOMU (JP)
Application Number:
PCT/JP2002/000191
Publication Date:
July 18, 2002
Filing Date:
January 15, 2002
Export Citation:
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Assignee:
NIPPON SODA CO (JP)
SATO DAISUKE (JP)
OOKA HIROHITO (JP)
INOUE TSUTOMU (JP)
International Classes:
B01J31/18; B01J31/24; C07B53/00; C07C213/00; C07F15/00; (IPC1-7): C07C215/46; B01J31/24; C07B53/00; C07C213/00; C07C215/08; C07C225/20; C07F9/50; C07F15/00; C07M7/00
Domestic Patent References:
WO2000041997A12000-07-20
Foreign References:
JPH1045721A1998-02-17
Other References:
SALVATORE, R.N. ET AL.: "CsOH-promoted chemoselective mono-N-alkylation of diamines of polyamines", TETRAHEDRON LETTERS, vol. 41, 2000, pages 9705 - 9708, XP004223120
Attorney, Agent or Firm:
Tokai, Yusaku c/o Nippon Soda Co. (Ltd. 2-1 Ohtemachi 2-chome Chiyoda-ku, Tokyo, JP)
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