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Title:
RXR HOMODIMER FORMATION AND BRIDGED BICYCLIC AROMATIC COMPOUNDS AND THEIR USE IN MODULATING GENE EXPRESSION
Document Type and Number:
WIPO Patent Application WO1994012880
Kind Code:
A3
Inventors:
PFAHL MAGNUS
ZHANG XIAO-KUN
LEHMANN JURGEN M
DAWSON MARCIA I
CAMERION JAMES F
HOBBS PETER D
JONG LING
Application Number:
US9311492W
Publication Date:
September 29, 1994
Filing Date:
November 24, 1993
Export Citation:
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Assignee:
LA JOLLA CANCER RESEARCH FOUNDATION
SRI INTERNATIONAL
International Classes:
G01N33/50; A61K31/19; A61K31/335; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/385; A61K31/39; A61P3/00; A61P3/02; A61P5/12; A61P17/00; A61P31/12; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07C63/49; C07C63/66; C07C65/36; C07C69/738; C07C69/76; C07C233/64; C07D311/58; C07D317/30; C07D319/06; C07D327/04; C07D333/22; C07D333/38; C07D339/06; C07D339/08; C07D409/04; C07K14/705; C12N15/09; G01N33/15; G01N33/53; G01N33/566; G01N33/68; G01N33/74; (IPC1-7): G01N33/566; G01N33/50; C07K14/705; C07D339/08; C07D339/06; C07D327/04; C07D319/06; C07D317/30; C07D409/04; C07D333/38; C07C63/49; C07C63/66; C07C65/36; A61K31/335; A61K31/19
Domestic Patent References:
WO1993025223A11993-12-23
Foreign References:
EP0260162A11988-03-16
Other References:
NATURE, vol.358, 13 August 1992, LONDON GB pages 587 - 591 XIAO-KUN ZHANG ET AL. 'Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid'
SCIENCE, vol.258, 18 December 1992 pages 1944 - 1946 J]RGEN M. LEHMANN ET AL. 'Retinoids selective for retinoid X receptor response pathways'
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