Title:
RYANODINE RECEPTOR INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/082940
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a medicament containing as an active ingredient a compound having ryanodine inhibitory activity, in particular, RyR1 inhibitory activity. Provided is an agent for treating or preventing ryanodine receptor-related diseases, the agent containing as an active ingredient a compound represented by formula (I) (all of the symbols in the formula are defined as in the description) or a pharmaceutically acceptable salt thereof.
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Inventors:
MURAYAMA, Takashi (2-1-1 Hongo, Bunkyo-k, Tokyo 21, 〒1138421, JP)
KUNIHIRO, Nagomi Kurebayashi (2-1-1 Hongo, Bunkyo-k, Tokyo 21, 〒1138421, JP)
KAGECHIKA, Hiroyuki (5-45 Yushima 1-chome, Bunkyo-k, Tokyo 10, 〒1138510, JP)
MORI, Shuichi (5-45 Yushima 1-chome, Bunkyo-k, Tokyo 10, 〒1138510, JP)
YUASA, Mari (5-45 Yushima 1-chome, Bunkyo-k, Tokyo 10, 〒1138510, JP)
KUNIHIRO, Nagomi Kurebayashi (2-1-1 Hongo, Bunkyo-k, Tokyo 21, 〒1138421, JP)
KAGECHIKA, Hiroyuki (5-45 Yushima 1-chome, Bunkyo-k, Tokyo 10, 〒1138510, JP)
MORI, Shuichi (5-45 Yushima 1-chome, Bunkyo-k, Tokyo 10, 〒1138510, JP)
YUASA, Mari (5-45 Yushima 1-chome, Bunkyo-k, Tokyo 10, 〒1138510, JP)
Application Number:
JP2018/039542
Publication Date:
May 02, 2019
Filing Date:
October 24, 2018
Export Citation:
Assignee:
JUNTENDO EDUCATIONAL FOUNDATION (2-1-1, Hongo Bunkyo-k, Tokyo 21, 〒1138421, JP)
NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (5-45, Yushima 1-chome Bunkyo-k, Tokyo 10, 〒1138510, JP)
NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (5-45, Yushima 1-chome Bunkyo-k, Tokyo 10, 〒1138510, JP)
International Classes:
A61K31/47; A61K31/4741; A61P21/02; A61P21/04; A61P29/02; A61P43/00; C07D215/56; C07D471/04; C07D491/056; A61P9/00; A61P9/06
Domestic Patent References:
| WO2007130499A2 | 2007-11-15 |
Foreign References:
| JPS61106557A | 1986-05-24 | |||
| JPS55100365A | 1980-07-31 | |||
| JPS56128703A | 1981-10-08 | |||
| JPS61122272A | 1986-06-10 | |||
| JPS4731312B1 | ||||
| GB1070333A | 1967-06-01 | |||
| US3149104A | 1964-09-15 | |||
| JPS5492992A | 1979-07-23 | |||
| US3966743A | 1976-06-29 | |||
| US3287458A | 1966-11-22 | |||
| JP2005533087A | 2005-11-04 | |||
| JP2015514736A | 2015-05-21 | |||
| JP2007024705A | 2007-02-01 | |||
| JP2017216924A | 2017-12-14 |
Other References:
DATABASE Database Registry [online] American Chemical Society; 11 November 2007 (2007-11-11), retrieved from STN Database accession no. 1267926-53-3
MURAYAMA, T ET AL.: "Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels", MOLECULAR PHARMACOLOGY, vol. 94, no. 1, July 2018 (2018-07-01), pages 722 - 730, XP055594636, ISSN: 1521-0111, DOI: 10.1124/mol.117.111468
MURAYAMA, T ET AL.: "Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels", MOLECULAR PHARMACOLOGY, vol. 94, no. 1, July 2018 (2018-07-01), pages 722 - 730, XP055594636, ISSN: 1521-0111, DOI: 10.1124/mol.117.111468
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (Sawanotsuru Ningyocho Bldg, 1-3-8 Nihonbashi Ningyocho, Chuo-k, Tokyo 13, 〒1030013, JP)
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