Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
S-ADENOSYL METHIONINE DECARBOXYLASE INHIBITION FOR THE TREATMENT OF A HERPES SIMPLEX VIRUS INFECTION
Document Type and Number:
WIPO Patent Application WO2004033417
Kind Code:
A3
Abstract:
The invention relates to the inhibition of S-adenosyl methionine decarboxylase for the prevention and/or the treatment of a herpes simplex virus infection.

Inventors:
DIAZ JEAN-JACQUES (FR)
GRECO ANNA (FR)
Application Number:
IB0304636W
Publication Date:
July 22, 2004
Filing Date:
October 09, 2003
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
INST NAT SANTE RECH MED (FR)
DIAZ JEAN-JACQUES (FR)
GRECO ANNA (FR)
International Classes:
A61K31/15; A61P31/22; C07C281/18; C12N15/11; (IPC1-7): C07C281/18; A61K31/15; A61P31/22; C12N15/11
Foreign References:
EP0358536A21990-03-14
US4027039A1977-05-31
US4032659A1977-06-28
EP0456133A11991-11-13
US4971986A1990-11-20
Other References:
KARVONEN E ET AL: "IRREVERSIBLE INHIBITION OF PUTRESCINE-STIMULATED S ADENOSYL-L-METHIONINE DECARBOXYLASE BY BERENIL AND PENTAMIDINE", BIOCHEMICAL JOURNAL, vol. 231, no. 1, 1985, pages 165 - 170, XP008027265, ISSN: 0264-6021
THOMAS THERSIA ET AL: "Structure-activity relations of S-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells", BREAST CANCER RESEARCH AND TREATMENT, vol. 39, no. 3, 1996, pages 293 - 306, XP008027257, ISSN: 0167-6806
SIU LILLIAN L ET AL: "A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.", CLINICAL CANCER RESEARCH: AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. UNITED STATES JUL 2002, vol. 8, no. 7, July 2002 (2002-07-01), pages 2157 - 2166, XP002269172, ISSN: 1078-0432
STANEK J ET AL: "4-Amidinoindan-1-one 2'-amidinohydrazone: A new potent and selective inhibitor of S-adenosylmethionine decarboxylase", JOURNAL OF MEDICINAL CHEMISTRY 1993 UNITED STATES, vol. 36, no. 15, 1993, pages 2168 - 2171, XP002269173, ISSN: 0022-2623
Download PDF: