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Patent Searching and Data


Title:
S-ADENOSYL METHIONINE DECARBOXYLASE INHIBITION FOR THE TREATMENT OF A HERPES SIMPLEX VIRUS INFECTION
Document Type and Number:
WIPO Patent Application WO2004033417
Kind Code:
A3
Abstract:
The invention relates to the inhibition of S-adenosyl methionine decarboxylase for the prevention and/or the treatment of a herpes simplex virus infection.

Inventors:
DIAZ JEAN-JACQUES (FR)
GRECO ANNA (FR)
Application Number:
IB0304636W
Publication Date:
July 22, 2004
Filing Date:
October 09, 2003
Export Citation:
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Assignee:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
DIAZ, JEAN-JACQUES
GRECO, ANNA
International Classes:
A61K31/15; A61P31/22; C07C281/18; C12N15/11; (IPC1-7): C07C281/18; A61K31/15; A61P31/22; C12N15/11
Foreign References:
EP0358536A21990-03-14
US4027039A1977-05-31
US4032659A1977-06-28
EP0456133A11991-11-13
US4971986A1990-11-20
Other References:
KARVONEN E ET AL: "IRREVERSIBLE INHIBITION OF PUTRESCINE-STIMULATED S ADENOSYL-L-METHIONINE DECARBOXYLASE BY BERENIL AND PENTAMIDINE" BIOCHEMICAL JOURNAL, vol. 231, no. 1, 1985, pages 165-170, XP008027265 ISSN: 0264-6021
THOMAS THERSIA ET AL: "Structure-activity relations of S-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells" BREAST CANCER RESEARCH AND TREATMENT, vol. 39, no. 3, 1996, pages 293-306, XP008027257 ISSN: 0167-6806
SIU LILLIAN L ET AL: "A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies." CLINICAL CANCER RESEARCH: AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. UNITED STATES JUL 2002, vol. 8, no. 7, July 2002 (2002-07), pages 2157-2166, XP002269172 ISSN: 1078-0432
STANEK J ET AL: "4-Amidinoindan-1-one 2'-amidinohydrazone: A new potent and selective inhibitor of S-adenosylmethionine decarboxylase" JOURNAL OF MEDICINAL CHEMISTRY 1993 UNITED STATES, vol. 36, no. 15, 1993, pages 2168-2171, XP002269173 ISSN: 0022-2623
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