Title:
S CRYSTAL FORM OF IVABRADINE HYDROCHLORIDE, AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/101072
Kind Code:
A1
Abstract:
Disclosed are a new S crystal form of Ivabradine hydrochloride, and preparation method and pharmaceutical composition thereof. The powder diffraction spectrum of the S crystal form of Ivabradine hydrochloride has characteristic peaks when 2θ is 8.5±0.2, 11.5±0.2, 14.6±0.2, 15.3±0.2, 16.1±0.2, 17.1±0.2, 17.4±0.2, 17.8±0.2, 18.6±0.2, 19.3±0.2, 21.6±0.2, 21.9±0.2 and 27.2±0.2, and, by DSC measurement, has an endothermic crystal transformation peak with a characteristic peak value of 111.60C and an exothermic crystal transformation peak with a characteristic peak value of 136.90C, and a melting decomposition peak with a characteristic peak value of 194.90C. S crystal form products are easy to dry, have high purity and stability, and are convenient for long-term storage without particular temperature and humidity requirements; the preparation method thereof facilitates industrial production, and has great application value and market value.
Inventors:
ZHANG XIAOBO (CN)
CUI DONGDONG (CN)
ZHANG TIANXIANG (CN)
CUI DONGDONG (CN)
ZHANG TIANXIANG (CN)
Application Number:
PCT/CN2014/087405
Publication Date:
July 09, 2015
Filing Date:
September 25, 2014
Export Citation:
Assignee:
BEIJING LUNARSUN PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/55; C07D223/16; A61P9/04; A61P9/10
Domestic Patent References:
| WO2012025940A1 | 2012-03-01 | |||
| WO2008146308A2 | 2008-12-04 | |||
| WO2013064427A1 | 2013-05-10 |
Foreign References:
| CN103864690A | 2014-06-18 | |||
| CN101805289A | 2010-08-18 | |||
| CN103012269A | 2013-04-03 |
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