S1-5-CONTAINING PROTEIN PREPARATION

WIPO Patent Application WO/2006/004066

A1

It is found out that age-related diseases or symptoms are induced in a knockout mouse lacking the function of S1-5 gene. It is also clarified by histological analysis that the bone mineral content, the bone density and the bone strength are lowered in this knockout mouse while the osteoclast count is increased in its bone tissue. By analyzing the osteoclastogenesis ability in vitro using bone marrow-origin cells of the knockout mouse, it is also clarified that this mouse has accelerated osteoclastogenesis ability and large-sized osteoclasts compared with a wild type mouse. It is disclosed that the addition of purified S1-5 protein to this in vitro system lowers the osteoclastogenesis ability.

NAKAJIMA TOSHIHIRO (JP)
YAGISHITA NAOKO (JP)
AMANO TETSUYA (JP)

PCT/JP2005/012251

January 12, 2006

July 01, 2005

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LOCOMOGENE INC (JP)
NAKAJIMA TOSHIHIRO (JP)
YAGISHITA NAOKO (JP)
AMANO TETSUYA (JP)

A01K67/027; A61K38/17; A61P19/00; C12N15/09; C12N5/16; G01N33/15; G01N33/50; (IPC1-7): A01K67/027; A61K38/17; A61P19/00; C12N5/16; C12N15/09; G01N33/15; G01N33/50

WO2001077327A1	2001-10-18
WO2002052007A1	2002-07-04

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ENLERMANN J. ET AL: "Cloning, expression and characterization of the murine Efempl, a gene mutated in Doyne-Homeycomb retinal dystrophy.", GENE EXPR PATTERNS., vol. 3, no. 4, 2003, pages 441 - 447, XP002991791

Shimizu, Hatsushi (1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, JP)

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