Title:
SARS-CoV-2-DERIVED POLYNUCLEOTIDE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/145884
Kind Code:
A1
Abstract:
Provided are: a polynucleotide that includes (i) a base sequence according to any of SEQ ID NOS: 1-3, (ii) a base sequence in which one to three bases have been deleted, substituted, inserted, or added in a base sequence according to any of SEQ ID NOS: 1-3, or (iii) a base sequence having 60% or greater sequence identity with a base sequence according to any of SEQ ID NOS: 1-3, the polynucleotide having activity to promote replication of the coronavirus when present in coronavirus-infected cells; a mimic thereof; an inhibitor thereof; and the use of these.
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Inventors:
SAITO HIROHIDE (JP)
TOMONAGA KEIZO (JP)
TAKAYAMA KAZUO (JP)
MAKINO AKIKO (JP)
HASHIMOTO RINA (JP)
ONO HIROKI (JP)
TOMONAGA KEIZO (JP)
TAKAYAMA KAZUO (JP)
MAKINO AKIKO (JP)
HASHIMOTO RINA (JP)
ONO HIROKI (JP)
Application Number:
PCT/JP2023/002669
Publication Date:
August 03, 2023
Filing Date:
January 27, 2023
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
A61K45/00; C12N15/113; A61P31/14; C12N5/10; C12N7/00; C12N7/06
Domestic Patent References:
| WO2021237297A1 | 2021-12-02 | |||
| WO2021152181A1 | 2021-08-05 |
Other References:
PAWLICA PAULINA, YARIO THERESE A., WHITE SYLVIA, WANG JIANHUI, MOSS WALTER N., HUI PEI, VINETZ JOSEPH M., STEITZ JOAN A.: "SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 118, no. 52, 28 December 2021 (2021-12-28), XP093081052, ISSN: 0027-8424, DOI: 10.1073/pnas.2116668118
MENG FEI, SIU GILMAN KIT-HANG, MOK BOBO WING-YEE, SUN JIAHONG, FUNG KITTY S. C., LAM JIMMY YIU-WING, WONG NONTHAPHAT KENT, GEDEFAW: "Viral MicroRNAs Encoded by Nucleocapsid Gene of SARS-CoV-2 Are Detected during Infection, and Targeting Metabolic Pathways in Host Cells", CELLS, vol. 10, no. 7, 12 July 2021 (2021-07-12), pages 1762, XP093081056, DOI: 10.3390/cells10071762
ROY SAWRAB, SHARMA BINAYOK, MAZID MD. ISHTIAQUE, AKHAND RUBAIAT NAZNEEN, DAS MOUMITA, MARUFATUZZAHAN MARUFATUZZAHAN, CHOWDHURY TAN: "Identification and host response interaction study of SARS-CoV-2 encoded miRNA-like sequences: an in silico approach", COMPUTERS IN BIOLOGY AND MEDICINE, NEW YORK, NY, US, vol. 134, 1 July 2021 (2021-07-01), US , pages 104451, XP093081060, ISSN: 0010-4825, DOI: 10.1016/j.compbiomed.2021.104451
MENG FEI, SIU GILMAN KIT-HANG, MOK BOBO WING-YEE, SUN JIAHONG, FUNG KITTY S. C., LAM JIMMY YIU-WING, WONG NONTHAPHAT KENT, GEDEFAW: "Viral MicroRNAs Encoded by Nucleocapsid Gene of SARS-CoV-2 Are Detected during Infection, and Targeting Metabolic Pathways in Host Cells", CELLS, vol. 10, no. 7, 12 July 2021 (2021-07-12), pages 1762, XP093081056, DOI: 10.3390/cells10071762
ROY SAWRAB, SHARMA BINAYOK, MAZID MD. ISHTIAQUE, AKHAND RUBAIAT NAZNEEN, DAS MOUMITA, MARUFATUZZAHAN MARUFATUZZAHAN, CHOWDHURY TAN: "Identification and host response interaction study of SARS-CoV-2 encoded miRNA-like sequences: an in silico approach", COMPUTERS IN BIOLOGY AND MEDICINE, NEW YORK, NY, US, vol. 134, 1 July 2021 (2021-07-01), US , pages 104451, XP093081060, ISSN: 0010-4825, DOI: 10.1016/j.compbiomed.2021.104451
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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