Title:
STEREOSELECTIVE Tc-99m LIGANDS
Document Type and Number:
WIPO Patent Application WO1999040882
Kind Code:
A3
Abstract:
The present invention concerns novel ligands, represented by Formulae (I), (II), (I') and (II'), that form complexes with a radioactive metal through a chelate bond. The complexes are useful in radiodiagnostic compositions employed for imaging. In said formulae, X, R<1> and R<2>, R<3> and R<4>, R<5> and R<6>, m and n are defined herein. The compounds of the invention avoid the formation of diastereomers based on incorporating [TcO]<+3>N2S2 as a chelating moiety since these compounds form only one isomer when complexed with [<99m>Tc][TcO]<+>.
Inventors:
KUNG HANK F (US)
KUNG MEI-PING (US)
ZHUANG ZHI-PING (US)
KUNG MEI-PING (US)
ZHUANG ZHI-PING (US)
Application Number:
PCT/US1999/002513
Publication Date:
November 04, 1999
Filing Date:
February 05, 1999
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
KUNG HANK F (US)
KUNG MEI PING (US)
ZHUANG ZHI PING (US)
KUNG HANK F (US)
KUNG MEI PING (US)
ZHUANG ZHI PING (US)
International Classes:
A61K51/04; (IPC1-7): A61K51/00; C07F13/00
Domestic Patent References:
| WO1994022494A1 | 1994-10-13 |
Foreign References:
| US4883862A | 1989-11-28 | |||
| US5279811A | 1994-01-18 |
Other References:
KASINA S, ET AL.: "TISSUE DISTRIBUTION PROPERTIES OF TECHNETIUM-99M-DIAMIDE-DIMERCAPTIDE COMPLEXES AND POTENTIAL USE A RENAL RADIOPHARMACEUTICALS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 29, no. 10, 1 May 1986 (1986-05-01), US, pages 1933 - 1940, XP002921580, ISSN: 0022-2623, DOI: 10.1021/jm00160a023
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