SACCHAROMYCES CEREVISIAE MUTANT STRAINS FOR PRODUCING SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE AND METHODS FOR PRODUCING SAME

Title:

SACCHAROMYCES CEREVISIAE MUTANT STRAINS FOR PRODUCING SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE AND METHODS FOR PRODUCING SAME

Document Type and Number:

WIPO Patent Application WO/2022/124639

Kind Code:

A1

Abstract:

Provided are: a saccharomyces cerevisiae mutant strain for producing sphingosine; a saccharomyces cerevisiae mutant strain for producing sphingosine-1-phosphate; methods for producing same; and a method for producing sphingosine or sphingosine-1-phosphate by using the strains. Particularly, provided is a Saccharomyces cerevisiae mutant strain for producing sphingosine, into which a human sphingolipid desaturase 1 (hDES1) gene and an alkaline ceramidase 1 (ACER1) gene are introduced.

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Inventors:

YU BYUNG JO (KR)
LEE SUNG JIN (KR)
JANG JI YEON (KR)
JANG IN SEUNG (KR)

Application Number:

PCT/KR2021/017220

Publication Date:

June 16, 2022

Filing Date:

November 23, 2021

Export Citation:

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Assignee:

KOREA INST IND TECH (KR)

International Classes:

C12N15/81; C12N9/02; C12N9/12; C12N9/16; C12N9/80; C12P9/00; C12P13/00

Foreign References:

KR20200031489A	2020-03-24
US20110262025A1	2011-10-27
JP2018525017A	2018-09-06
US20020042358A1	2002-04-11

Other References:

WEI SUN , RUIJUAN XU , WEI HU , JUNFEI JIN , HEATHER A.CRELLIN , JACEK BIELAWSKI ,ZDZISLAW M.SZULC , BRUCE H.THIERS , LINA M.OBEID: "Upregulation of the Human Alkaline Ceramidase 1 and Acid Ceramidase Mediates Calcium-Induced Differentiation of Epidermal Keratinocytes", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 2008, no. 128, 1 January 2008 (2008-01-01), NL , pages 389 - 397, XP002547556, ISSN: 0022-202X, DOI: 10.1038/SJ.JID.5701025
J. SAMBROOK ET AL.: "A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS, article "Molecular Cloning"
F.M. AUSUBEL ET AL.: "Current Protocols in Molecular Biology", JOHN WILEY & SONS, INC.

Attorney, Agent or Firm:

KIM, Hyun Jae (KR)

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