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Title:
SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/148357
Kind Code:
A1
Abstract:
The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate can be prepared by subjecting a compound to a deprotection reaction. The intermediate can be used as a raw material and further synthesized to form a sacubitril compound. The method provided by the invention has the advantages of easily acquired raw materials, simple techniques, cost effectiveness, and environmental friendliness, and is therefore suitable for industrial production.

Inventors:
CHEN, Lei (Dongyangguang Hi-tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
SUN, Guodong (Dongyangguang Hi-tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
HAN, Xiaodong (Dongyangguang Hi-tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
LI, Shun (Dongyangguang Hi-tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
ZENG, Jiebin (Dongyangguang Hi-tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
WANG, Zhongqing (Dongyangguang Hi-tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
LUO, Zhonghua (Dongyangguang Hi-tech Park, Zhen An Road No. 368 Shang Sha, Chang An Tow, Dongguan Guangdong 1, 523871, CN)
Application Number:
CN2017/075097
Publication Date:
September 08, 2017
Filing Date:
February 28, 2017
Export Citation:
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Assignee:
SUNSHINE LAKE PHARMA CO., LTD. (Northern Industrial Area, Songshan LakeDongguan, Guangdong 0, 523000, CN)
International Classes:
C07C59/84; C07C49/245; C07C49/255; C07C51/09; C07C69/738; C07C231/02; C07C233/47; C07C235/78; C07D498/04; C12P13/00
Domestic Patent References:
WO2008083967A22008-07-17
Foreign References:
CN105924355A2016-09-07
CN104860894A2015-08-26
CN104557600A2015-04-29
US4604383A1986-08-05
Other References:
LAURENCE, E.B. ET AL.: "A Simple Asymmetric Synthesis of 2-Substituted Pyrrolidines and 5-Substituted Pyrrolidinones", JOURNAL OF ORGANIC CHEMISTRY, vol. 6, 31 March 1992 (1992-03-31), pages 1656 - 1662, XP055413738, ISSN: 0022-3263
NORMAN, A. ET AL.: "A Simple Synthesis of y and delta-Keto a-Amino Acid Derivatives", TETRAHEDRON LETTERS, vol. 31, no. 44, 1 January 1990 (1990-01-01), pages 6311 - 6312, XP055575961, ISSN: 0040-4039
MO, XIAN ET AL.: "Chemoenzymatic Synthesis of Glutamic Acid Analogues: Substrate Specificity and Synthetic Applications of Branched Chain Aminotransferase from Escherichia coli", JOURNAL OF ORGANIC CHEMISTRY, vol. 20, 24 August 2007 (2007-08-24), pages 7560 - 7566, XP055413744, ISSN: 0022-3263
See also references of EP 3424899A4
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