Title:
SALICYLIC ACID BERBERINE-TYPE ALKALOID QUATERNARY AMMONIUM COMPOUND AND USE THEREOF FOR PREPARING MEDICINES
Document Type and Number:
WIPO Patent Application WO/2020/177744
Kind Code:
A1
Abstract:
Disclosed in the present invention are a salicylic acid berberine-type alkaloid quaternary ammonium compound as shown in general formula (I), a preparation method therefor, solubility characteristics, a pharmaceutical composition and an application thereof in the preparation of medicinal products. The salicylic acid berberine-type alkaloid quaternary ammonium compound as shown in general formula (I) may be prepared by an organic synthesis method, and shows obvious solubility of alcohol-water mixed solvents. The compound may be conveniently prepared on a large scale, and has significant anti-ulcerative colitis activity, with non-toxic or low toxicity characteristics. The compound may be used to prepare products for preventing, relieving and/or treating ulcerative colitis.
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Inventors:
QIN HAILIN (CN)
WU LIANQIU (CN)
LI JING (CN)
ZHANG HAIJING (CN)
DENG ANJUN (CN)
TANG XIAONAN (CN)
LI XIANG (CN)
LI XIANG (CN)
WANG YUFEI (CN)
LI ZHIHONG (CN)
WANG WENJIE (CN)
WU LIANQIU (CN)
LI JING (CN)
ZHANG HAIJING (CN)
DENG ANJUN (CN)
TANG XIAONAN (CN)
LI XIANG (CN)
LI XIANG (CN)
WANG YUFEI (CN)
LI ZHIHONG (CN)
WANG WENJIE (CN)
Application Number:
PCT/CN2020/078049
Publication Date:
September 10, 2020
Filing Date:
March 05, 2020
Export Citation:
Assignee:
INST MATERIA MEDICA CAMS (CN)
International Classes:
C07D455/03; A61K31/04; A61K31/4375; A61P29/00
Foreign References:
| CN103204850A | 2013-07-17 | |||
| CN1295573A | 2001-05-16 |
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