Title:
SALMONELLA STRAIN FOR PREVENTION AND TREATMENT OF CANCER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/098213
Kind Code:
A1
Abstract:
The present invention relates to a DNA construct and a strain into which a recombinant vector comprising the DNA construct is introduced. The DNA construct according to the present invention expresses an antioncogene operably linked downstream of first and second promoters in a host strain or cell, and thus has cancer prevention and treatment effects. In addition, the DNA construct of the present invention enables an antioncogene to be expressed at an appropriate dose for cancer treatment, by controlling doxycycline treatment.
Inventors:
MIN JUNG-JOON (KR)
HONG YEONGJIN (KR)
YOU SUNG-HWAN (KR)
HUY NGUYEN DINH (KR)
HONG YEONGJIN (KR)
YOU SUNG-HWAN (KR)
HUY NGUYEN DINH (KR)
Application Number:
PCT/KR2021/016267
Publication Date:
May 12, 2022
Filing Date:
November 09, 2021
Export Citation:
Assignee:
UNIV NAT CHONNAM IND FOUND (KR)
International Classes:
C12N15/74; A61K35/74; A61P35/00; C07K14/195; C07K14/255
Foreign References:
| KR20150102093A | 2015-09-04 | |||
| KR20160121276A | 2016-10-19 | |||
| JP2010508861A | 2010-03-25 |
Other References:
JIANG SHENG-NAN, PARK SEUNG-HWAN, LEE HEE JUNG, ZHENG JIN HAI, KIM HYUNG-SEOK, BOM HEE-SEUNG, HONG YEONGJIN, SZARDENINGS MICHAEL, : "Engineering of Bacteria for the Visualization of Targeted Delivery of a Cytolytic Anticancer Agent", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 21, no. 11, 1 November 2013 (2013-11-01), US , pages 1985 - 1995, XP055928239, ISSN: 1525-0016, DOI: 10.1038/mt.2013.183
JIN HAI ZHENG, NGUYEN VU H., JIANG SHENG-NAN, PARK SEUNG-HWAN, TAN WENZHI, HONG SEOL HEE, SHIN MYUNG GEUN, CHUNG IK-JOO, HONG YEON: "Supplementary Materials for Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin", SCIENCE TRANSLATIONAL MEDICINE, vol. 9, no. 376, 8 February 2017 (2017-02-08), pages eaak9537, XP055629859, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aak9537
MOL THER., vol. 21, no. 11, 2013, pages 1985 - 1995
JIN HAI ZHENG, NGUYEN VU H., JIANG SHENG-NAN, PARK SEUNG-HWAN, TAN WENZHI, HONG SEOL HEE, SHIN MYUNG GEUN, CHUNG IK-JOO, HONG YEON: "Supplementary Materials for Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin", SCIENCE TRANSLATIONAL MEDICINE, vol. 9, no. 376, 8 February 2017 (2017-02-08), pages eaak9537, XP055629859, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aak9537
MOL THER., vol. 21, no. 11, 2013, pages 1985 - 1995
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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