Title:
SALT AND CRYSTAL FORM OF PYRAZOLE-CONTAINING POLYCYCLIC DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/258007
Kind Code:
A1
Abstract:
An acid salt and a crystal form of a pyrazole-containing polycyclic derivative represented by formula (I-a), and a preparation method therefor, a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and an intermediate for preparing the derivative. In particular, the present invention relates to the use of the salt and the crystal form of the compound represented by general formula (I-a) as a P2X3 inhibitor in the preparation of a drug for treating neurogenic diseases.
Inventors:
DONG HUA (CN)
GUO LINSONG (CN)
GUO LINSONG (CN)
Application Number:
PCT/CN2022/097828
Publication Date:
December 15, 2022
Filing Date:
June 09, 2022
Export Citation:
Assignee:
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61P29/00; C07D471/12
Domestic Patent References:
| WO2021115225A1 | 2021-06-17 |
Foreign References:
| CN105683190A | 2016-06-15 | |||
| CN108727377A | 2018-11-02 | |||
| US4072680A | 1978-02-07 | |||
| CN104540828A | 2015-04-22 | |||
| CN2020134264W | 2020-12-07 |
Other References:
GHOZLAN SAID A. S., RAMADAN MUHAMMED A., ABDELMONIEM AMR M., ABDELHAMID ISMAIL A.: "N-(Pyrazol-5-yl)cyanoacetamide in heterocyclic synthesis: synthesis of novel N-(pyrazol-5-yl)pyridine-3,5-dicarbonitrile, pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-7-carbonitrile and pyrazolo[4,3-e]pyrido[1,2-a]pyrimidine-6,8-dicarbonitrile moieties", ARKIVOC, vol. 2019, no. 5, 30 December 2018 (2018-12-30), pages 30 - 41, XP093012949, DOI: 10.24820/ark.5550190.p010.801
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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