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Title:
SALT OF INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/076324
Kind Code:
A1
Abstract:
Disclosed are a salt of indoleamine-2,3-dioxygenase inhibitor and a preparation method therefor. In particular, disclosed are a salt of a compound of formula I and a variety of amorphous substances and polymorphs thereof, wherein the definitions of each group are as described in the description. The salt has a stable structure, good light stability, thermostability, nonhygroscopic and pharmacokinetic properties, and good solubility, significantly improved purity and bioavailability, and is particularly suitable for the development and production of an IDO enzyme inhibitor with high quality.

Inventors:
WANG, Zhaoyin (No.345 Lingling Road, Xuhui District, Shanghai 2, 200032, CN)
HU, Xinbo (No.345 Lingling Road, Xuhui District, Shanghai 2, 200032, CN)
GUO, Wei (No.345 Lingling Road, Xuhui District, Shanghai 2, 200032, CN)
Application Number:
CN2018/110682
Publication Date:
April 25, 2019
Filing Date:
October 17, 2018
Export Citation:
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Assignee:
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (No.345 Lingling Road, Xuhui District, Shanghai 2, 200032, CN)
International Classes:
C07D271/08; A61K31/4245; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P35/00
Domestic Patent References:
WO2017101884A12017-06-22
WO2018095432A12018-05-31
WO2018072697A12018-04-26
Foreign References:
CN105481789A2016-04-13
CN107176933A2017-09-19
CN107304191A2017-10-31
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (Room 106, Building No. 1 Universal High-Tech Plaza, 958 Zhen Bei Road, Putuo District, Shanghai 3, 200333, CN)
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