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Title:
SALT OF PHENYLPROPIONAMIDE DERIVATIVE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/109934
Kind Code:
A1
Abstract:
The present invention provides a salt of a phenylpropionamide derivative and a preparation method therefor. The present invention specifically provides an acetate, hydrochloride, phosphate, citrate, benzoate, or fumarate of 4-amino-1-((2R,5R,8R,14R)-2-(4-aminobutyl)-8-benzyl-5-isobutyl-4,7,10-trioxo-14-phenyl-3,6,9,12-tetraazapentadecan-1-acyl)piperidine-4-carboxylic acid, and a preparation method therefor. The salt of the compound of formula (I) of the present invention has good stability, and the simple process thereof facilitates easy operation. The invention is better suited for clinical treatment.

Inventors:
WANG LIN (CN)
YE JINGQUAN (CN)
SHAO QIYUN (CN)
FENG JUN (CN)
HE FENG (CN)
CAO XIAOLI (CN)
MA YAHUI (CN)
Application Number:
CN2018/119309
Publication Date:
June 13, 2019
Filing Date:
December 05, 2018
Export Citation:
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Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D295/18; A61K38/07; A61P29/00; C07K1/06; C07K5/107
Domestic Patent References:
WO2014089019A12014-06-12
WO2020071398A12020-04-09
WO2008060552A22008-05-22
WO1999032510A11999-07-01
WO2013184794A22013-12-12
WO2014089019A12014-06-12
WO2014184356A12014-11-20
WO2015065867A22015-05-07
WO2017211272A12017-12-14
Foreign References:
CN108290926A2018-07-17
US20160250277A12016-09-01
CN104271552A2015-01-07
US8809278B22014-08-19
CN201711272474A2017-12-06
CN2017087328W2017-06-06
US20110212882A12011-09-01
Other References:
BIOORGANIC MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 9, 2007, pages 2448 - 2451
CHEMMEDCHEM, vol. 10, no. 7, 2015, pages 1232 - 1239
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 42, no. 39, 2003, pages 4793 - 4795
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 322, no. 2, 2007, pages 686 - 694
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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